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Role of microglial cells in photoreceptor degeneration
Neural Regeneration Research, 2019 Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world. They comprise various diseases, but retinitis pigmentosa is the most frequently observed. Retinitis pigmentosa is commonly limited to the eye,
Johnny Di Pierdomenico +4 more
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The Renewal of Photoreceptor Cell Outer Segments. [PDF]
Journal of Cell Biology, 1967 The utilization of methionine-3H by retinal photoreceptor cells has been studied by radioautographic technique in the rat, mouse, and frog. In all three species, the labeled amino acid is concentrated initially in the inner segment of the cell. Within 24 hr, the radioactive material is displaced to the base of the outer segment, where it accumulates as
Richard W Young, R W Young
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Bone marrow-derived mononuclear stem cells in the treatment of retinal degenerations
Neural Regeneration Research, 2022 Retinal degenerative diseases affecting the outer retina in its many forms (inherited, acquired or induced) are characterized by photoreceptor loss, and represent currently a leading cause of irreversible vision loss in the world.
Diego Garcia-Ayuso +4 more
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Cell Death and Disease, 2023 Retinal detachment (RD) occurs in several major retinal conditions and often causes irreversible vision loss due to photoreceptor cell death. Retinal residential microglial cells are activated following RD and participate in photoreceptor cell death via ...
Wenchuan Zhou +5 more
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Tzu Chi Medical Journal, 2020 The visual impairment associated with inherited retinal degeneration and age-related degeneration of photoreceptors is causing substantial challenges in finding effective therapies.
Rupendra Shrestha +2 more
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Microfluidic processing of stem cells for autologous cell replacement
Stem Cells Translational Medicine, 2021 Autologous photoreceptor cell replacement is one of the most promising approaches currently under development for the treatment of inherited retinal degenerative blindness.
Nicholas E. Stone +4 more
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Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors. [PDF]
PLoS Genetics, 2015 Histamine is an important chemical messenger that regulates multiple physiological processes in both vertebrate and invertebrate animals. Even so, how glial cells and neurons recycle histamine remains to be elucidated.
Ying Xu +5 more
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PLoS ONE, 2012 In non-mammalian vertebrates, the pineal gland functions as the central pacemaker that regulates the circadian rhythms of animal behavior and physiology. We generated a transgenic zebrafish line [Tg(Gnat2:gal4-VP16/UAS:nfsB-mCherry)] in which the E. coli
Xinle Li +5 more
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Using electroretinograms and multi-model inference to identify spectral classes of photoreceptors and relative opsin expression levels [PDF]
PeerJ, 2017 Understanding how individual photoreceptor cells factor in the spectral sensitivity of a visual system is essential to explain how they contribute to the visual ecology of the animal in question.
Nicolas Lessios
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Role of Oxidative Stress in Retinal Photoreceptor Cell Death in N-Methyl-N-nitrosourea–Treated Mice
Journal of Pharmacological Sciences, 2012 This study aimed to investigate whether oxidative stress contributes to retinal cell death in a mouse model of photoreceptor degeneration induced by N-methyl-N-nitrosourea (MNU).
Kazuhiro Tsuruma +5 more
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