Results 41 to 50 of about 4,871,943 (300)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Neurotransmitter modulation of extracellular H+ fluxes from isolated retinal horizontal cells of the skate

, 2004
Self-referencing H+-selective microelectrodes were used to measure extracellular H+ fluxes from horizontal cells isolated from the skate retina. A standing H+ flux was detected from quiescent cells, indicating a higher concentration of free hydrogen ions
Verzi, Michael P., Birnbaum, Andrea D., Yamoah, Ebenezer N., Molina, Anthony J.A, Hammar, Katherine, Malchow, Robert Paul, Smith, Peter J.S.   +6 more
core   +1 more source

Rapamycin Improved Retinal Function and Morphology in a Mouse Model of Retinal Degeneration

Frontiers in Neuroscience, 2022
The retina is an important visual organ, which is responsible for receiving light signals and transmitting them to the optic nerve center step by step.
Meng Zhao, Meng Zhao, Houting Lv, Houting Lv, Na Yang, Na Yang, Guang-Hua Peng, Guang-Hua Peng   +7 more
doaj   +1 more source

Multimodal Optoelectronic Synapses for Neuromorphic Intelligence: Coupling Light, Electrical, Thermal, and Beyond

Advanced Functional Materials, EarlyView.
This review revisits optoelectronic neuromorphic devices that extend from unimodal sensing toward multimodal perception. Five types of stimuli‐to‐output information flow that are classified based on the device roles within the system and applications are summarized and discussed.
Jihyun Shin, Junhyung Cho, Wangmyung Choi, Jaehyun Hur, Jae Kyeong Jeong, Ulrike Kraft, Hocheon Yoo   +6 more
wiley   +1 more source

Do photoreceptor cells cause the development of retinal vascular disease? [PDF]

, 2017
The retinal vasculature is affected in a number of clinically important retinopathies, including diabetic retinopathy. There has been a considerable amount of research into the pathogenesis of retinal microvascular diseases, but the potential ...
Timothy S. Kern, Kern, Timothy S
core   +1 more source

Photoreceptor Cell Degeneration in Abcr –/– Mice [PDF]

, 2009
Mice harboring a null mutation in Abca4/Abcr serve as a model of autosomal recessive Stargardt disease. Consistent with the human retinal disorder, deficiency in Abcr is associated with substantial accumulations of lipofuscin pigments in retinal pigment epithelial (RPE) cells.
Li, Wu, Taka, Nagasaki, Janet R, Sparrow
openaire   +2 more sources

Light‐Induced Field‐Tunneling Synapses in Solution‐Processed Van Der Waals Heterostructures for Scalable, Retina‐Inspired Optical Sensing

Advanced Functional Materials, EarlyView.
A scalable, solution‐processed WSe2/ZrO2‐x van der Waals heterostructure realizes a light‐induced field‐tunneling synapse (LIFTS) that activates exclusively under bright illumination, emulating the photopic adaptation of the human retina at the device level.
Kijeong Nam, Jihyun Kim, Soobeen Ji, In Soo Kim, Sejin Kim, Eungseon Yeon, Do Kyung Hwang, Iva Plutnarová, Zdeněk Sofer, Sang Min Won, Joohoon Kang   +10 more
wiley   +1 more source

Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa

eLife, 2013
Next-generation and Sanger sequencing were combined to identify disease-causing USH2A mutations in an adult patient with autosomal recessive RP. Induced pluripotent stem cells (iPSCs), generated from the patient’s keratinocytes, were differentiated into ...
Budd A Tucker, Robert F Mullins, Luan M Streb, Kristin Anfinson, Mari E Eyestone, Emily Kaalberg, Megan J Riker, Arlene V Drack, Terry A Braun, Edwin M Stone   +9 more
doaj   +1 more source

KIT ligand protects against both light-induced and genetic photoreceptor degeneration

eLife, 2020
Photoreceptor degeneration is a major cause of blindness and a considerable health burden during aging but effective therapeutic or preventive strategies have not so far become readily available.
Huirong Li, Lili Lian, Bo Liu, Yu Chen, Jinglei Yang, Shuhui Jian, Jiajia Zhou, Ying Xu, Xiaoyin Ma, Jia Qu, Ling Hou   +10 more
doaj   +1 more source

An Adaptive Inhibitory WSe2 Transistor for Retinomorphic In‐Sensor Image Processing

Advanced Functional Materials, EarlyView.
Conventional retinomorphic devices typically require deliberate gate‐bias tuning for each illumination condition. In this paper, we demonstrate an adaptive inhibitory WSe2 transistor that uses photo‐induced regime shift between the subthreshold and accumulation modes to achieve decision‐free, intensity‐adaptive image processing within a single pixel ...
Juhwan Baek, Junhwa Oh, Hyeonjung Kim, Minsik Park, Haein Cho, Jin Young Park, Hyeonchang Son, Taeyun Kim, Sung‐Un An, Yamin Zhang, Hyeon‐Jin Shin, Seyong Oh, Dong‐Ho Kang   +12 more
wiley   +1 more source