Results 31 to 40 of about 4,871,943 (300)

Chemically-induced photoreceptor degeneration and protection in mouse iPSC-derived three-dimensional retinal organoids

Stem Cell Research, 2017
Induced pluripotent stem cells (iPSCs), which can be differentiated into various tissues and cell types, have been used for clinical research and disease modeling.
Shin-ichiro Ito, Akishi Onishi, Masayo Takahashi   +2 more
doaj   +1 more source

Insights into the evolutionary origin of the pineal color discrimination mechanism from the river lamprey

BMC Biology, 2021
Background Pineal-related organs in cyclostomes, teleosts, amphibians, and reptiles exhibit color opponency, generating antagonistic neural responses to different wavelengths of light and thereby sensory information about its “color”.
Seiji Wada, Emi Kawano-Yamashita, Tomohiro Sugihara, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita   +5 more
doaj   +1 more source

Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179 [PDF]

, 2015
The rd1 mouse with a mutation in the Pde6b gene was the first strain of mice identified with a retinal degeneration. However, AAV-mediated gene supplementation of rd1 mice only results in structural preservation of photoreceptors, and restoration of the ...
Bainbridge, James W.B., Rizzi, M, Nishiguchi, KM, James W. B. Bainbridge, Kate Powell, Joana Ribeiro, Duran, Y, Ribeiro, J, Powell, K, Luhmann, UF, Azam, Selina A., Yanai Duran, Rizzi, Matteo, Livia S. Carvalho, Smith, Alexander J., Holthaus, Sophia Martha Kleine, Robin R. Ali, Ulrich F. O. Luhmann, Carvalho, Livia S., Er J. Smith, Koji M. Nishiguchi, Powell, Kate, Matteo Rizzi, Selina A. Azam, Carvalho, LS, Ali, RR, Holthaus, SM, Sophia-martha Kleine Holthaus, Bainbridge, JW, Ali, Robin R.; id_orcid, Luhmann, Ulrich F.O., Duran, Yanai, Azam, SA, Ribeiro, Joana, Smith, AJ, Nishiguchi, Koji M.   +35 more
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Three distinct roles for notch in Drosophila R7 photoreceptor specification. [PDF]

PLoS Biology, 2011
Receptor tyrosine kinases (RTKs) and Notch (N) proteins are different types of transmembrane receptors that transduce extracellular signals and control cell fate.
Andrew Tomlinson, Yannis Emmanuel Mavromatakis, Gary Struhl   +2 more
doaj   +1 more source

felwag/photoreceptor-pattern-analysis: Photoreceptor pattern analysis

, 2022
This FIJI macro intends to analyze the photoreceptor pattern in the retina. It has been applied to human retinal organoids immunostained for Müller glia markers (SLC1A3+RLBP1) and imaged en face (Völkner et al., in revision)
felwag
core   +1 more source

Neurogliogenesis and visual system development in "Drosophila" : genetic/genomic analysis of the "Glial cells missing" and "Egghead" genes [PDF]

, 2005
Complex nervous systems are made up by two major cell types, neuronal and glial cell types. A general observation that has been made by lineage analysis of neurogliogenesis in vertebrates and invertebrates is that neurons and glia often share common ...
Fan, Yun
core   +1 more source

STEREOLOGY AND SOME STRUCTURAL CORRELATES OF RETINAL AND PHOTORECEPTOR CELL FUNCTION

Image Analysis and Stereology, 2011
The retina is the part of the eye which detects light, transduces it into nerve impulses and plays a significant role in visual perception. Sensitivity to light is multi-factorial and depends on the properties of photopigment molecules, their synthesis ...
Terry M Mayhew
doaj   +1 more source

Lineage tracing reveals photoreceptor precursor cell subpopulations that contribute to murine retinogenesis

Frontiers in Cell and Developmental Biology
IntroductionCell-based therapies hold great promise for treating late-stage retinal degenerative diseases. However, photoreceptor cell transplantation has been limited by poor cellular integration, suggesting that an ideal population of donor cells has ...
Joseph J. Yano, Zhangyong Wei, Krishna J. Gajjar, Kaidi T. Barati-Stec, Emma Yang, Katherine E. Uyhazi   +5 more
doaj   +1 more source

Localization of acetylcholine-related molecules in the retina: implication of the communication from photoreceptor to retinal pigment epithelium. [PDF]

PLoS ONE, 2012
It has been long speculated that specific signals are transmitted from photoreceptors to the retinal pigment epithelium (RPE). However, such signals have not been identified.
Hidetaka Matsumoto, Koji Shibasaki, Motokazu Uchigashima, Amane Koizumi, Masashi Kurachi, Yasuhiro Moriwaki, Hidemi Misawa, Koichiro Kawashima, Masahiko Watanabe, Shoji Kishi, Yasuki Ishizaki   +10 more
doaj   +1 more source

Iroquois complex genes induce co-expression of rhodopsins in Drosophila. [PDF]

, 2008
The Drosophila eye is a mosaic that results from the stochastic distribution of two ommatidial subtypes. Pale and yellow ommatidia can be distinguished by the expression of distinct rhodopsins and other pigments in their inner photoreceptors (R7 and R8),
Mathias F Wernet, Desplan, C, Pichaud, F, Daniel Vasiliauskas, Vasiliauskas Daniel, Pichaud Franck, Celik, A, Cook Tiffany A, Vasiliauskas, D, Cook, TA, Mazzoni Esteban O, Franck Pichaud, Johnston, RJ, Wernet Mathias F, Esteban O Mazzoni, Mazzoni, EO, Arzu Celik, Robert J Johnston, Tiffany A Cook, Johnston Robert J, Claude Desplan, Celik Arzu, Desplan Claude, Wernet, MF   +23 more
core   +1 more source