In vitro transdifferentiation of human peripheral blood mononuclear cells to photoreceptor-like cells [PDF]
Biology Open, 2016 Direct reprogramming is a promising, simple and low-cost approach to generate target cells from somatic cells without using induced pluripotent stem cells.
Yukari Komuta +7 more
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A single Musashi gene allele is sufficient to maintain mouse photoreceptor cells. [PDF]
PLoS ONEIn vertebrates, two genes, Musashi1 (Msi1) and Musashi2 (Msi2), encode for highly similar Musashi protein paralogs. The Musashi proteins are known to bind to 3'-UTRs and control translation.
Bohye Jeong, Peter Stoilov
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Proteomic Profiling Revealed Mitochondrial Dysfunction in Photoreceptor Cells under Hyperglycemia. [PDF]
Int J Mol Sci, 2022 Diabetic retinopathy (DR) was identified as a leading cause of blindness and vision impairment in 2020. In addition to vasculopathy, DR has been found to involve retinal neurons, including amacrine cells and retinal ganglion cells.
Lam CH, Cheung JK, Tse DY, Lam TC.
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Differentiation of human olfactory mucosa mesenchymal stem cells into photoreceptor cells in vitro [PDF]
International Journal of Ophthalmology, 2017 AIM: To investigate whether the human olfactory mucosa mesenchymal stem cells (OM-MSCs) can differentiate into photoreceptor cells in vitro. METHODS: Through the olfactory mucosa adherent method, olfactory mucosa was isolated, cultured and identified in
Wen Lu +4 more
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Alterations in kainate receptor and TRPM1 localization in bipolar cells after retinal photoreceptor degeneration [PDF]
Frontiers in Cellular Neuroscience, 2015 Photoreceptor degeneration differentially impacts glutamatergic signaling in downstream On and Off bipolar cells. In rodent models, photoreceptor degeneration leads to loss of glutamatergic signaling in On bipolar cells, whereas Off bipolar cells appear ...
Jacqueline eGayet-Primo +1 more
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Mitofusins are required for specialized mitochondrial morphology and function of rod photoreceptor cells [PDF]
Frontiers in Cell and Developmental BiologyMitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these include elongated mitochondria in the inner segments and a distinct ...
Michael Landowski +24 more
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Role of glycolysis in retinal vascular endothelium, glia, pigment epithelium, and photoreceptor cells and as therapeutic targets for related retinal diseases [PDF]
International Journal of Ophthalmology, 2021 Glycolysis produces large amounts of adenosine triphosphate (ATP) in a short time. The retinal vascular endothelium feeds itself primarily through aerobic glycolysis with less ATP.
Ting-Ting Yang, Hui Li, Li-Jie Dong
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Stem Cells International, 2012 Purpose. Transplantation of stem, progenitor, or precursor cells has resulted in photoreceptor replacement and evidence of functional efficacy in rodent models of retinal degeneration.
H. Klassen +8 more
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Stem Cell Research & Therapy, 2021 Background Retinal regenerative therapies hold great promise for the treatment of inherited retinal degenerations (IRDs). Studies in preclinical lower mammal models of IRDs have suggested visual improvement following retinal photoreceptor precursors ...
Swathi Lingam +16 more
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Device-free isolation of photoreceptor cells from patient iPSC-derived retinal organoids [PDF]
JCI InsightAutologous photoreceptor cell replacement is one of the most promising strategies currently being developed for the treatment of patients with inherited retinal degenerative blindness.
Nicholas E. Stone +8 more
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