Results 21 to 30 of about 62,604 (264)
Frontiers in Cell and Developmental BiologyIntroductionCell-based therapies hold great promise for treating late-stage retinal degenerative diseases. However, photoreceptor cell transplantation has been limited by poor cellular integration, suggesting that an ideal population of donor cells has ...
Joseph J. Yano +5 more
doaj +1 more source
Localization of acetylcholine-related molecules in the retina: implication of the communication from photoreceptor to retinal pigment epithelium. [PDF]
PLoS ONE, 2012 It has been long speculated that specific signals are transmitted from photoreceptors to the retinal pigment epithelium (RPE). However, such signals have not been identified.
Hidetaka Matsumoto +10 more
doaj +1 more source
Stem Cells International, 2012 Purpose. Transplantation of stem, progenitor, or precursor cells has resulted in photoreceptor replacement and evidence of functional efficacy in rodent models of retinal degeneration.
H. Klassen +8 more
doaj +1 more source
eLife, 2013 Next-generation and Sanger sequencing were combined to identify disease-causing USH2A mutations in an adult patient with autosomal recessive RP. Induced pluripotent stem cells (iPSCs), generated from the patient’s keratinocytes, were differentiated into ...
Budd A Tucker +9 more
doaj +1 more source
Rapamycin Improved Retinal Function and Morphology in a Mouse Model of Retinal Degeneration
Frontiers in Neuroscience, 2022 The retina is an important visual organ, which is responsible for receiving light signals and transmitting them to the optic nerve center step by step.
Meng Zhao +7 more
doaj +1 more source
Photoreceptor Cell Degeneration in Abcr –/– Mice [PDF]
, 2009 Mice harboring a null mutation in Abca4/Abcr serve as a model of autosomal recessive Stargardt disease. Consistent with the human retinal disorder, deficiency in Abcr is associated with substantial accumulations of lipofuscin pigments in retinal pigment epithelial (RPE) cells.
Li, Wu, Taka, Nagasaki, Janet R, Sparrow
openaire +2 more sources
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Photoreceptor cell fate specification in vertebrates [PDF]
Development, 2015 Photoreceptors – the light-sensitive cells in the vertebrate retina – have been extremely well-characterized with regards to their biochemistry, cell biology and physiology. They therefore provide an excellent model for exploring the factors and mechanisms that drive neural progenitors into a differentiated cell fate in the nervous system. As a result,
Joseph A, Brzezinski, Thomas A, Reh
openaire +2 more sources
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
KIT ligand protects against both light-induced and genetic photoreceptor degeneration
eLife, 2020 Photoreceptor degeneration is a major cause of blindness and a considerable health burden during aging but effective therapeutic or preventive strategies have not so far become readily available.
Huirong Li +10 more
doaj +1 more source