Results 51 to 60 of about 107,639 (354)

Direct Conversion of Mouse Fibroblasts into Photoreceptor-like Cells

Cells
The purpose of our study is to explore the potential of a transcription factor-based strategy for directly converting mouse fibroblasts into photoreceptor-like cells.
Jia Xie, Sam Enayati, Dong Feng Chen, Jianwei Jiao, Liu Yang   +4 more
doaj   +1 more source

Global Transcriptional and Epigenetic Reconfiguration during Chemical Reprogramming of Human Retinal Pigment Epithelial Cells into Photoreceptor-like Cells

Cells, 2022
Retinal degenerative diseases are frequently caused by the loss of retinal neural cells such as photoreceptors. Cell replacement is regarded as one of the most promising therapies.
Xiaoqian Deng, Ryan Lee, Sin Yee Lim, Zheng Zhong, Jing Wang, Yizhi Liu, Guoping Fan   +6 more
doaj   +1 more source

670 nm light mitigates oxygen-induced degeneration in C57BL/6J mouse retina [PDF]

, 2016
BACKGROUND Irradiation with light wavelengths from the far red (FR) to the near infrared (NIR) spectrum (600 nm -1000 nm) has been shown to have beneficial effects in several disease models.
Albarracin, Rizalyn, Natoli, Riccardo, Provis, Jan, Rutar, Matthew, Valter, Krisztina   +4 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Effect of purified murine NGF on isolated photoreceptors of a rodent developing retinitis pigmentosa. [PDF]

PLoS ONE, 2015
A number of different studies have shown that neurotrophins, including nerve growth factor (NGF) support the survival of retinal ganglion neurons during a variety if insults.
Maria Luisa Rocco, Bijorn Omar Balzamino, Pamela Petrocchi Passeri, Alessandra Micera, Luigi Aloe   +4 more
doaj   +1 more source

Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]

, 2015
Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Ali, RR, Barber, AC, Graca, AB, Hippert, C, Pearson, RA, Smith, AJ, West, EL   +6 more
core   +1 more source

Ferroelectric Quantum Dots for Retinomorphic In‐Sensor Computing

Advanced Materials, EarlyView.
This work has provided a protocol for fabricating retinomorphic phototransistors by integrating ferroelectric ligands with quantum dots. The resulting device combines ferroelectricity, optical responsiveness, and low‐power operation to enable adaptive signal amplification and high recognition accuracy under low‐light conditions, while supporting ...
Tingyu Long, Huanyu Zhou, Jaewan Ko, Hongwei Tan, Jaemin Lim, Yanfei Zhao, Daehan Kang, Eojin Yoon, Gyeong‐Tak Go, Somin Kim, Seung‐Woo Lee, Chan‐Yul Park, Hyojun Choi, Hyeran Kim, Hyung Joong Yun, Sung Hyuk Park, Kwan Sik Park, Jeong Woo Park, Mungeun Kim, Yong Soo Cho, Ho Won Jang, Wenqiang Yang, Min Hyuk Park, Wan Ki Bae, Sebastiaan van Dijken, Joona Bang, Tae‐Woo Lee   +26 more
wiley   +1 more source

cGMP-grade human iPSC-derived retinal photoreceptor precursor cells rescue cone photoreceptor damage in non-human primates

Stem Cell Research & Therapy, 2021
Background Retinal regenerative therapies hold great promise for the treatment of inherited retinal degenerations (IRDs). Studies in preclinical lower mammal models of IRDs have suggested visual improvement following retinal photoreceptor precursors ...
Swathi Lingam, Zengping Liu, Binxia Yang, Wendy Wong, Bhav Harshad Parikh, Jun Yi Ong, Debbie Goh, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Gavin S. W. Tan, Graham E. Holder, Kakkad Regha, Veluchamy Amutha Barathi, Walter Hunziker, Gopal Lingam, Xianmin Zeng, Xinyi Su   +16 more
doaj   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

COCO enhances the efficiency of photoreceptor precursor differentiation in early human embryonic stem cell-derived retinal organoids

Stem Cell Research & Therapy, 2020
Background Significant progress has been made in cell replacement therapy for neural retinal diseases using retinal cells differentiated from human pluripotent stem cells.
Deng Pan, Xi-Xi Xia, Heng Zhou, Si-Qian Jin, Yang-Yan Lu, Hui Liu, Mei-Ling Gao, Zi-Bing Jin   +7 more
doaj   +1 more source