Results 101 to 110 of about 1,465,941 (244)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Lamps of dark ages

, 2008
Among lighting devices ponderable seat is taken by the lamps of dark ages. Among them new types of lighting devices are oily lamps and candlesticks, lampadci with the monogram of Hrista.
Маркович, М.
core  

Discriminating Planck reionisation histories with the kSZ effect

Astronomy & Astrophysics
The epoch of reionisation is a key phase in cosmic history, but its detailed evolution remains poorly constrained by current cosmic microwave background (CMB) observations.
Douspis M., Gorce A., Ilić S., McBride L., Muñoz-Echeverría M., Pointecouteau E., Salvati L., Tristram M.   +7 more
doaj   +1 more source

GUY HALSALL, WORLDS OF ARTHUR. FACTS AND FICTIONS OF THE DARK AGES

Journal of Ancient History and Archaeology, 2015
Guy Halsall, Worlds of Arthur. Facts and Fictions of the Dark Ages, Oxford: University Press, 2014. 384 pp.
Vlad Andrei Lazarescu
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

PRISMS: U37126, a very blue ISM-naked starburst at z = 10.255 with a nearly 100% Lyman continuum escape fraction

Astronomy & Astrophysics
We present very deep (≈11 hours on-source) JWST/MIRI low-resolution spectroscopy of the rest-frame optical emission of U37126, a UV-bright (MUV ≃ −20) mildly lensed (μ ≃ 2.2) galaxy at z = 10.255.
Marques-Chaves R., Álvarez-Márquez J., Colina L., Kendrew S., Abdurro’uf, Blanco-Prieto C., Boogaard L. A., Castellano M., Caputi K. I., Crespo-Gómez A., Fontana A., Fudamoto Y., Fujimoto S., García-Marín M., Harikane Y., Harish S., Hashimoto T., Hsiao T., Iani E., Inoue A. K., Langeroodi D., Lin R., Melinder J., Napolitano L., Östlin G., Pérez-González P. G., Prieto-Jiménez C., Rinaldi P., Rodríguez Del Pino B., Santini P., Sugahara Y., Varo-O’Ferrall A., Wright G., Zavala J.   +33 more
doaj   +1 more source

Suggestions for Escaping the Dark Ages for Pediatric Diffuse Intrinsic Pontine Glioma Treated with Radiotherapy: Analysis of Prognostic Factors from the National Multicenter Study. [PDF]

Cancer Res Treat, 2023
Kim HJ, Lee JH, Kim Y, Lim DH, Park SH, Ahn SD, Kim IA, Im JH, Chung JW, Kim JY, Kim IH, Yoon HI, Suh CO.   +12 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source