Results 81 to 90 of about 727,203 (295)

Dark-Ages Reionisation & Galaxy Formation Simulation XVI: The Thermal Memory of Reionisation

, 2019
Intergalactic medium temperature is a powerful probe of the epoch of reionisation, as information is retained long after reionisation itself. However, mean temperatures are highly degenerate with the timing of reionisation, with the amount heat injected ...
Davies, James E., Mesinger, Andrei, Mutch, Simon J., Poole, Gregory B., Qin, Yuxiang, Wyithe, J. Stuart B.   +5 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Detecting the 21 cm Signal from the Cosmic Dark Ages

The Astrophysical Journal
The cosmic “dark ages” is the period between the last scattering of the cosmic microwave background and the appearance of the first luminous sources, spanning redshifts 1100 ≳  z  ≳ 30.
Willow Smith, Jonathan C. Pober
doaj   +1 more source

MOND in the Early Universe

, 1998
I explore some consequences of Milgrom's modified dynamics for cosmology. There appear to be two promising tests for distinguishing MOND from CDM: (1) the rate of growth of structure and (2) the baryon fraction. These should be testable with observations
McGaugh, Stacy
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Behavioral characteristics of a chondrostean sturgeon species Acipenser baerii prelarvae in response to different environmental light intensities in a diel photoperiodic cycle

Journal of Animal Reproduction and Biotechnology, 2020
Behavioral response to a diel photoperiodicity (500 lx for 16 h, 5 lx for 4 h and < 0.5 lx for 4 h) and phototactic characteristics in dark conditions were examined with Siberian sturgeon Acipenser baerii (Chondrostei, Actinopterygii) prelarvae. Siberian
Eun Jeong Kim, Chulhong Park, Yoon Kwon Nam   +2 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The Spin-Resolved Atomic Velocity Distribution and 21-cm Line Profile of Dark-Age Gas

, 2006
The 21-cm hyperfine line of atomic hydrogen (HI) is a promising probe of the cosmic dark ages. In past treatments of 21-cm radiation it was assumed the hyperfine level populations of HI could be characterized by a velocity-independent ``spin temperature''
Allison, Babich, Barkana, Bharadwaj, Carilli, Chen, Christopher M. Hirata, Chuzhoy, Cooray, Dalgarno, Edmonds, Field, Field, Fixsen, Frye, Furlanetto, Furlanetto, Furlanetto, Gradshteyn, Hirata, Iliev, Iliev, Jamieson, Jamieson, Kolos, Kolos, Kris Sigurdson, Kuhlen, Kuhlen, Loeb, Madau, McQuinn, Morales, Naoz, Pritchard, Santos, Seager, Shapiro, Sigurdson, Smith, Smith, Tang, Wang, Wouthuysen, Zaldarriaga, Zygelman, Zygelman   +46 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source