Results 71 to 80 of about 727,203 (295)

A Next Generation Deep 2 micron Survey: Reconnoitering the Dark Ages

, 2011
The next generation 2 micron sky survey should target nascent galaxies in the epoch of reionization for spectroscopic followup on large telescopes. A 2.5 metre telescope at a site on the antarctic plateau has advantages for this purpose and for southern ...
Burton, Ichikawa, Jeremy Mould, Kaiser, Lascaux, Lawrence, Rousselot, Saunders, Sutherland, Zhao   +9 more
core   +1 more source

Clustering of Ionizing Sources [PDF]

, 1998
Using existing models for the evolution of clustering we show that the first sources are likely to be highly biased and thus strongly clustered. We compute intensity fluctuations for clustered sources in a uniform IGM.
Oh, Siang Peng
core   +3 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

The Magnitude of the Dark Ages 21 cm Signal in the Context of Existing Early and Late Time Constraints on ΛCDM

The Astrophysical Journal Letters
The dark ages 21 cm signal is a promising probe of the currently unobserved infant Universe between the formation of the cosmic microwave background around z  ≈ 1100 and the first galaxies around z  ≈ 30.
Harry T. J. Bevins
doaj   +1 more source

Cosmological constraints combining H(z), CMB shift and SNIa observational data

, 2007
Recently H(z) data obtained from differential ages of galaxies have been proposed as a new geometrical probe of dark energy. In this paper we use those data, combined with other background tests (CMB shift and SNIa data), to constrain a set of general ...
Alam U, Bond J R, Chimento L P, Davis T M, Denison D G T, Dicus D A Repko W W, Elgaroy O, Elgaroy O Multamäki T, Elisabetta Majerotto, Gong Y Wang A Wu Q Zhang Y Z, Gong Y G, Goobar A, Jassal H K, Jeffreys H, Kurek A Szydlowski M, Lazkoz R, Nesseris S, Ruth Lazkoz, Rydbeck S Fairbairn M Goobar A, Sahni V, Sahni V, Serra P Heavens A Melchiorri A, Starobinsky A A, Trotta R, Trotta R, Tsujikawa S, Turok N, Väliviita J, Väliviita J, Wang Y Mukherjee P, Wasserman L, Wood-Vasey W M, Wright E L, Wright E L, Wu P X, Xu L I Zhang C W Chang B R Liu H Y, Zech G, Zhang H Zhu Z H, Zunckel C Trotta R   +38 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The American Dark Ages and the Terrorist Witch in Season of the Witch

CINEJ Cinema Journal, 2013
In this article we argue that Season of the Witch (Sena, 2011) is not to be analyzed according to its faithfulness to the known historical sources, but only by understanding medievalist codes, traditions and (filmic) intertextuality.
Tom Vercruysse
doaj   +1 more source