Results 51 to 60 of about 727,203 (295)

A smoother end to the dark ages

, 2011
Independent lines of evidence suggest that the first stars, which ended the cosmic dark ages, came in pairs, rather than singly. This could change the prevailing view that the early Universe had a Swiss-cheese-like appearance.Comment: Nature News and ...
A Stacy, A Venkatesan, IF Mirabel, M Dijkstra, M Ricotti, MJ Turk, P Madau, SCO Glover, SP Oh, SR Furlanetto, T Abel, V Bromm, X Chen, Z Haiman, Z Haiman, Zoltán Haiman   +15 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Measuring the intergalactic medium correlation length at 5 < z < 6.1: A fast change at the end of reionization

Astronomy & Astrophysics
Context. The Lyman-α forest of high-redshift quasars is a powerful probe of the late stages of the epoch of reionization (EoR), in particular thanks to the presence of Gunn-Peterson troughs.
Spina Benedetta, Bosman Sarah E. I., Maity Barun, Davies Frederick B.   +3 more
doaj   +1 more source

Climate Variability in Central Europe during the Last 2500 Years Reconstructed from Four High-Resolution Multi-Proxy Speleothem Records

Geosciences, 2021
The Late Holocene was characterized by several centennial-scale climate oscillations including the Roman Warm Period, the Dark Ages Cold Period, the Medieval Warm Period and the Little Ice Age.
Sarah Waltgenbach, Dana F. C. Riechelmann, Christoph Spötl, Klaus P. Jochum, Jens Fohlmeister, Andrea Schröder-Ritzrau, Denis Scholz   +6 more
doaj   +1 more source

Particle decays during the cosmic dark ages [PDF]

, 2003
We consider particle decays during the cosmic dark ages with two aims: (1) to explain the high optical depth reported by the Wilkinson Microwave Anisotropy Probe (WMAP), and (2) to provide new constraints to the parameter space for decaying particles. We
Chen, Xuelei, Kamionkowski, Marc
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Establishing a relationship between the cosmological 21 cm power spectrum and interferometric closure phases

Astronomy & Astrophysics
Context. Measurements of the cosmic 21 cm background need to achieve a high dynamic range to isolate it from bright foreground emissions. Instrumental calibration inaccuracies can compromise the spectral fidelity of the smooth foreground continuum ...
Keller P. M., Nikolic B., Thyagarajan N.
doaj   +1 more source

Growing and laying performances of two varieties of Noi chickens raised in an intensive farming system

Vietnam Journal of Science, Technology and Engineering, 2022
This study was conducted to compare the black and dark brown varieties of Noi purebred chickens raised in an intensive farming system. A total of 600 black and 600 dark brown Noi chickens were observed starting from 1 day after hatching.
Vu Hoa Dang, Van Diep Duong, Thi Huong Nguyen, Ngoc Khanh Do, Thi Hue Le, Minh Hieu Nguyen, Thi Ut Tran, Hoang Nguyen Nguyen, Thuy Nhung Dang   +8 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The 21cm–galaxy cross-correlation: Realistic forecast for 21cm signal detection and reionisation constraints

Astronomy & Astrophysics
Context. The 21cm–galaxy cross-correlations are expected to play a key role in the confirmation of the cosmological 21cm signal. Aims. We investigate which survey configurations detect the 21cm–Lyman-α emitter (LAE) cross-correlation signal and assess ...
Hutter Anne, Heneka Caroline
doaj   +1 more source