Results 51 to 60 of about 1,465,941 (244)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Stellar Archeology: What White Dwarf Stars Tell Us About the History of the Galaxy [PDF]

Journal of Astronomy and Space Sciences, 2012
White dwarf stars have played important roles in rather diverse areas of astrophysics. This paper outlines how these stellar remnants, especially those in widely separated “fragile” binaries, have provided unique leverage on difficult astrophysical ...
Terry D. Oswalt
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

POLAR

Astronomy & Astrophysics
Context. Galaxies may suffer some starburst and quenched periods in their history due to galaxy mergers and feedback. However, semi-numerical simulations of the Epoch of Reionization (EoR) do not accurately model the effects of the star formation history
Ma Qing-Bo, Ghara Raghunath, Ciardi Benedetta, Acharya Anshuman, Yue Bin, Iliev Ilian T., Koopmans Léon V. E., Mellema Garrelt, Zaroubi Saleem   +8 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Sensitivity of the redshifted 21 cm signal from the Dark Ages to parameters of primordial magnetic fields

Astronomy & Astrophysics
We analyse the impact of the decaying magnetic turbulence of primordial magnetic fields (PMFs) and ambipolar diffusion on the ionisation and thermal history of the Dark Ages Universe (30 ≤ z ≤ 300), and its imprint on the spectral profile of the global ...
Novosyadlyj B., Kulinich Yu., Fortuna N., Rudakovskyi A.   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Generative models of 21 cm Epoch of Reionisation lightcones with 3D scattering transforms

Astronomy & Astrophysics
The 21 cm signal from the Epoch of Reionisation (EoR) is observed as a 3D dataset known as a lightcone, consisting of two spatial sky plane axes and a redshift (frequency) axis.
Hothi Ian, Allys Erwan, Semelin Benoit, Meriot Romain   +3 more
doaj   +1 more source

Possible combinations of early and late time cosmologies through BAO scales

European Physical Journal C: Particles and Fields, 2023
The theoretical scenarios of early universe and late time accelerated expansion constitute an open problem in cosmology. Relative Baryon Acoustic Oscillation (BAO) scales measured by 6dFGS, $$\mathrm SDSS+2dFGRS$$ S D S S + 2 d F G R S , BOSS DR11 Ly ...
Sanjeev Kalita, Chayanika Rabha
doaj   +1 more source