Results 51 to 60 of about 112,066 (261)

Britain in the Seventies – Our Unfinest Hour?

Revue Française de Civilisation Britannique, 2017
In popular recollection, the 1970s have gone down as the dark ages, Britain’s gloomiest period since the second world war, set between Harold Wilson’s ‘swinging sixties’ and Margaret Thatcher’s divisive eighties. Forty years on, it is appropriate for the
Kenneth O. Morgan
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The R/renaissance(s), Humanists And Classics

The Journal of Classics Teaching, 2018
First, where does the Renaissance fit in chronologically with other periods of the past? There is general agreement that the Renaissance should be dated from 1300 to 1650, though some believe that a more accurate and meaningful starting date would be ...
Jerome Moran
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

The 21cm–galaxy cross-correlation: Realistic forecast for 21cm signal detection and reionisation constraints

Astronomy & Astrophysics
Context. The 21cm–galaxy cross-correlations are expected to play a key role in the confirmation of the cosmological 21cm signal. Aims. We investigate which survey configurations detect the 21cm–Lyman-α emitter (LAE) cross-correlation signal and assess ...
Hutter Anne, Heneka Caroline
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

The Magnitude of the Dark Ages 21 cm Signal in the Context of Existing Early and Late Time Constraints on ΛCDM

The Astrophysical Journal Letters
The dark ages 21 cm signal is a promising probe of the currently unobserved infant Universe between the formation of the cosmic microwave background around z  ≈ 1100 and the first galaxies around z  ≈ 30.
Harry T. J. Bevins
doaj   +1 more source

Before its time: A remarkably evolved protocluster core at z = 7.88

Astronomy & Astrophysics
Protoclusters represent the most extreme environments in the very early Universe. They form from large-scale dark matter overdensities, harbouring an overabundance of galaxies fed by large gas reservoirs.
Witten Callum, Oesch Pascal A., McClymont William, Meyer Romain A., Fudamoto Yoshinobu, Sijacki Debora, Laporte Nicolas, Bennett Jake S., Simmonds Charlotte, Giovinazzo Emma, Danhaive A. Lola, Ciesla Laure, Carvajal-Bohorquez Cristian, Trebitsch Maxime   +13 more
doaj   +1 more source