Results 41 to 50 of about 1,465,941 (244)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

UV slopes of star-forming galaxies in strong-lensing fields at the epoch of reionisation with JWST

Astronomy & Astrophysics
Context. UV slopes (β) are a powerful diagnostic for galaxies at the epoch of reionisation, tracing star formation, interstellar medium ionisation, and the escape fraction fesc of ionising photons.
Felicioni Giordano, Bradač Maruša, Asada Yoshihisa, Martis Nicholas S., Sarrouh Ghassan T. E., Desprez Guillaume, Rihtaršič Gregor, Jagga Naadiyah, Harshan Anishya, Judež Jon, Willott Chris J., Abraham Roberto, Brammer Gabriel, Estrada-Carpenter Vince, Matharu Jasleen, Muzzin Adam, Noirot Gaël, Sawicki Marcin, Withers Sunna, Markov Vladan, Mérida Rosa M., Pirc Jevšenak Vesna, Tripodi Roberta   +22 more
doaj   +1 more source

Statistical Detection of the He ii Transverse Proximity Effect: Evidence for Sustained Quasar Activity for >25 Million Years

Frontiers in Astronomy and Space Sciences, 2017
The reionization of helium at z ~ 3 is the final phase transition of the intergalactic medium and supposed to be driven purely by quasars. The He ii transverse proximity effect—enhanced He ii transmission in a background sightline caused by the ionizing ...
Tobias M. Schmidt, Tobias M. Schmidt, Gabor Worseck, Joseph F. Hennawi, Joseph F. Hennawi, J. Xavier Prochaska, Neil H. M. Crighton, Zarija Lukić, Jose Oñorbe   +8 more
doaj   +1 more source

Is skin autofluorescence (SAF) representative of dermal advanced glycation endproducts (AGEs) in dark skin? A pilot study

Heliyon, 2020
Aims: Non-invasively assessed skin autofluorescence (SAF) measures advanced glycation endproducts (AGEs) in the dermis. SAF correlates with dermal AGEs in Caucasians and Asians, but studies in dark-skinned subjects are lacking.
Isabella M. Atzeni, Jeltje Boersema, Hendri H. Pas, Gilles F.H. Diercks, Jean L.J.M. Scheijen, Casper G. Schalkwijk, Douwe J. Mulder, Piet van der Zee, Andries J. Smit   +8 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Dark-ages reionization and galaxy formation simulation-XI. Clustering and halo masses of high redshift galaxies

, 2017
We investigate the clustering properties of Lyman-break galaxies (LBGs) at z similar to 6 - 8. Using the semi-analytical model MERAXES constructed as part of the dark-ages reionization and galaxy-formation observables from numerical simulation (DRAGONS ...
Alan Duffy (18925381), Simon J. Mutch (19005473), J. Stuart B. Wyithe (19010369), Jaehong Park (45792), Han-Seek Kim (19073195), Paul M. Geil (19010342), Gregory B. Poole (18999008), Chuanwu Liu (19015052), Andrei Mesinger (16164626), Michele Trenti (19015199)   +9 more
core   +1 more source

Weighing gas-rich starless halos: Dark matter parameter inference based on gas distributions

Astronomy & Astrophysics
Context. Reionization-limited H I clouds (RELHICs) are starless dark matter halos that retain a significant neutral hydrogen (H I) reservoir. The gas resides in near hydrostatic equilibrium within the dark matter potential and in thermal equilibrium with
Turini Francesco, Benítez-Llambay Alejandro   +1 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Reionisation time field reconstruction from 21-cm maps: Investigating predictor coherence in warm dark matter cosmology

Astronomy & Astrophysics
Context. The reionisation time field treion(r) captures the entire history of cosmic reionisation by mapping the moment where each region of the Universe became ionised.
Hiegel Julien, Aubert Dominique, Thélie Émilie, Ibata Rodrigo, Mai Nicolas   +4 more
doaj   +1 more source