Results 41 to 50 of about 727,203 (295)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The SPHINX public data release

Astronomy & Astrophysics
Context. Low-ionisation state (LIS) metal absorption lines, such as Si II λ1526, are widely used to trace the properties and dynamics of the interstellar medium (ISM) in galaxies.
Mauerhofer Valentin, Blaizot Jérémy, Garel Thibault, Verhamme Anne, Gazagnes Simon, Kerutt Josephine, Michel-Dansac Leo, Parker Kaelee S., Rosdahl Joakim, Saldana-Lopez Alberto, Trebitsch Maxime, Kimm Taysun, Ocvirk Pierre, Teyssier Romain   +13 more
doaj   +1 more source

Energy Injection And Absorption In The Cosmic Dark Ages

, 2012
Dark matter annihilation or de-excitation, decay of metastable species, or other new physics may inject energetic electrons and photons into the photon-baryon fluid during and after recombination.
Slatyer, Tracy R.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

POLAR

Astronomy & Astrophysics
Context. Galaxies may suffer some starburst and quenched periods in their history due to galaxy mergers and feedback. However, semi-numerical simulations of the Epoch of Reionization (EoR) do not accurately model the effects of the star formation history
Ma Qing-Bo, Ghara Raghunath, Ciardi Benedetta, Acharya Anshuman, Yue Bin, Iliev Ilian T., Koopmans Léon V. E., Mellema Garrelt, Zaroubi Saleem   +8 more
doaj   +1 more source

Neutralino Annihilations and the Gas Temperature in the Dark Ages

, 2007
Assuming the dark matter is made entirely from neutralinos, we re-visit the role of their annihilation on the temperature of diffuse gas in the high redshift universe. We consider neutralinos of particle mass 36 GeV and 100 GeV, respectively.
Abel, Adi Nusser, Albuquerque, Baltz, Baltz, Benson, Berezhiani, Bromm, Chen, Chuzhoy, Colafrancesco, Diemand, Diemand, Ellis, Felten, Field, Furlanetto, Green, Gunn, Haardt, Hansen, Jungman, Kamionkowski, Kasuya, Kasuya, Mapelli, Padmanabhan, Peebles, Peebles, Pieri, Pieri, Pierpaoli, Press, Ripamonti, Rudaz, Sciama, Shull, Silk, Spergel, Stecker, Tasitsiomi, Thomas, Turner, Ullio, Zacharia Myers, Zhang   +45 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Dark ages reionization & galaxy formation simulation XII: Bubbles at dawn

, 2017
Direct detection of regions of ionized hydrogen (HII) has been suggested as a promising probe of cosmic reionization. Observing the redshifted 21-cm signal of hydrogen from the epoch of reionization (EoR) is a key scientific driver behind new-generation,
Duffy, Alan R., Geil, Paul M., Mesinger, Andrei, Mutch, Simon J., Poole, Gregory B., Wyithe, J. Stuart B.   +5 more
core   +1 more source

21-cm observations and warm dark matter models [PDF]

, 2019
Observations of the redshifted 21-cm signal (in absorption or emission) allow us to peek into the epoch of "dark ages" and the onset of reionization. These data can provide a novel way to learn about the nature of dark matter, in particular about the ...
Boyarsky, Alexey, Iakubovskyi, Dmytro, Ruchayskiy, Oleg, Rudakovskyi, Anton, Valkenburg, Wessel   +4 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source