Results 21 to 30 of about 112,066 (261)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Signatures of very massive stars in the epoch of reionization

Astronomy & Astrophysics
We present ultra-deep (≃20 − 30 hours) rest-frame UV spectroscopy with NIRSpec of two UV-bright galaxies at z ∼ 8.7, CEERS-1019 and CEERS-1025 (Zneb ≃ 0.1 Z⊙), obtained as part of the JWST Cycle 4 SPURS large program.
Marques-Chaves R., Martins F., Schaerer D., Dessauges-Zavadsky M., Palacios A.   +4 more
doaj   +1 more source

Statistical Detection of the He ii Transverse Proximity Effect: Evidence for Sustained Quasar Activity for >25 Million Years

Frontiers in Astronomy and Space Sciences, 2017
The reionization of helium at z ~ 3 is the final phase transition of the intergalactic medium and supposed to be driven purely by quasars. The He ii transverse proximity effect—enhanced He ii transmission in a background sightline caused by the ionizing ...
Tobias M. Schmidt, Tobias M. Schmidt, Gabor Worseck, Joseph F. Hennawi, Joseph F. Hennawi, J. Xavier Prochaska, Neil H. M. Crighton, Zarija Lukić, Jose Oñorbe   +8 more
doaj   +1 more source

Is skin autofluorescence (SAF) representative of dermal advanced glycation endproducts (AGEs) in dark skin? A pilot study

Heliyon, 2020
Aims: Non-invasively assessed skin autofluorescence (SAF) measures advanced glycation endproducts (AGEs) in the dermis. SAF correlates with dermal AGEs in Caucasians and Asians, but studies in dark-skinned subjects are lacking.
Isabella M. Atzeni, Jeltje Boersema, Hendri H. Pas, Gilles F.H. Diercks, Jean L.J.M. Scheijen, Casper G. Schalkwijk, Douwe J. Mulder, Piet van der Zee, Andries J. Smit   +8 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

GLIMPSE-D: Metallicity decline in faint galaxies: Implications for [O III]+Hβ luminosity function and re-ionisation budget

Astronomy & Astrophysics
We report the measurement of the R3 = [O III] λ5008/Hβ ratios for 54 galaxies in the GLIMPSE-D survey. Thanks to gravitational lensing, our sample includes galaxies with −20 ≲ MUV 
Korber Damien, Schaerer Daniel, Marques-Chaves Rui, Adamo Angela, Basu Arghyadeep, Chisholm John, Dessauges-Zavadsky Miroslava, McQuinn Kristen. B. W., Saldana-Lopez Alberto, Atek Hakim, Endsley Ryan, Fujimoto Seiji, Furtak Lukas J., Kokorev Vasily, Naidu Rohan P., Pan Richard   +15 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mass distribution of population III star clusters: A-SLOTH predictions for JWST observability

Astronomy & Astrophysics
Context. Detecting population III (pop. III) stars remains a major observational challenge. Their Balmer-series recombination line emission, redshifted into the infrared at z ∼ 5 − 11, has been proposed as a potential tracer.
Lipatova Veronika, Glover Simon C. O., Klessen Ralf S., Liu Boyuan   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source