Results 31 to 40 of about 112,066 (261)

POLAR

Astronomy & Astrophysics
Context. Galaxies may suffer some starburst and quenched periods in their history due to galaxy mergers and feedback. However, semi-numerical simulations of the Epoch of Reionization (EoR) do not accurately model the effects of the star formation history
Ma Qing-Bo, Ghara Raghunath, Ciardi Benedetta, Acharya Anshuman, Yue Bin, Iliev Ilian T., Koopmans Léon V. E., Mellema Garrelt, Zaroubi Saleem   +8 more
doaj   +1 more source

Stellar Archeology: What White Dwarf Stars Tell Us About the History of the Galaxy [PDF]

Journal of Astronomy and Space Sciences, 2012
White dwarf stars have played important roles in rather diverse areas of astrophysics. This paper outlines how these stellar remnants, especially those in widely separated “fragile” binaries, have provided unique leverage on difficult astrophysical ...
Terry D. Oswalt
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Sensitivity of the redshifted 21 cm signal from the Dark Ages to parameters of primordial magnetic fields

Astronomy & Astrophysics
We analyse the impact of the decaying magnetic turbulence of primordial magnetic fields (PMFs) and ambipolar diffusion on the ionisation and thermal history of the Dark Ages Universe (30 ≤ z ≤ 300), and its imprint on the spectral profile of the global ...
Novosyadlyj B., Kulinich Yu., Fortuna N., Rudakovskyi A.   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Generative models of 21 cm Epoch of Reionisation lightcones with 3D scattering transforms

Astronomy & Astrophysics
The 21 cm signal from the Epoch of Reionisation (EoR) is observed as a 3D dataset known as a lightcone, consisting of two spatial sky plane axes and a redshift (frequency) axis.
Hothi Ian, Allys Erwan, Semelin Benoit, Meriot Romain   +3 more
doaj   +1 more source

Dark triad and cyber aggression among Chinese adolescents during COVID-19: A moderated mediation model

Frontiers in Psychology, 2022
During the COVID-19 pandemic, the use of online learning has become a necessary choice for students, and would increase the probability of cyber aggression (CA).
Zhen Zhang, Shengnan Bian, Hui Zhao, Chunhui Qi   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A GLIMPSE into the very faint end of the Hβ+[O III]λλ4960,5008 luminosity function at z ∼ 7 – 9 behind Abell S1063

Astronomy & Astrophysics
We used the ultra-deep GLIMPSE JWST/NIRCam survey to constrain the faint end of the [O III]+Hβ luminosity function (LF) down to 1039erg s−1 at z ∼ 7 − 9 behind the lensed Hubble Frontier Field galaxy cluster Abell S1063.
Korber Damien, Chemerynska Iryna, Furtak Lukas J., Atek Hakim, Endsley Ryan, Schaerer Daniel, Chisholm John, Kokorev Vasily, Saldana-Lopez Alberto, Adamo Angela, Muñoz Julian B., Oesch Pascal A., Meyer Romain, Marques-Chaves Rui, Fujimoto Seiji   +14 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source