Results 31 to 40 of about 1,465,941 (244)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

GLIMPSE-D: Metallicity decline in faint galaxies: Implications for [O III]+Hβ luminosity function and re-ionisation budget

Astronomy & Astrophysics
We report the measurement of the R3 = [O III] λ5008/Hβ ratios for 54 galaxies in the GLIMPSE-D survey. Thanks to gravitational lensing, our sample includes galaxies with −20 ≲ MUV 
Korber Damien, Schaerer Daniel, Marques-Chaves Rui, Adamo Angela, Basu Arghyadeep, Chisholm John, Dessauges-Zavadsky Miroslava, McQuinn Kristen. B. W., Saldana-Lopez Alberto, Atek Hakim, Endsley Ryan, Fujimoto Seiji, Furtak Lukas J., Kokorev Vasily, Naidu Rohan P., Pan Richard   +15 more
doaj   +1 more source

Do multiple physiological OCT biomarkers indicate age-related decline in rod mitochondrial function in C57BL/6J mice?

Frontiers in Neuroscience, 2023
PurposeTo test the hypothesis that rod photoreceptor mitochondria function in vivo progressively declines over time.Methods2, 12, and 24 month-old dark- and light-adapted C57BL/6J (B6J) mice were examined by OCT. We measured (i) an index of mitochondrial
Cole Goodman, Robert H. Podolsky, Karen Lins Childers, Robin Roberts, Ryan Katz, Rida Waseem, Anuhya Paruchuri, Josh Stanek, Bruce A. Berkowitz   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The cosmic dark ages

, 2010
How did the elements come into existence, and how we can use them to count the number of stars in the early Universe? This talk will reveal the dark ages of the Universe.
Emma Ryan-Weber (18924055)
core   +1 more source

Mass distribution of population III star clusters: A-SLOTH predictions for JWST observability

Astronomy & Astrophysics
Context. Detecting population III (pop. III) stars remains a major observational challenge. Their Balmer-series recombination line emission, redshifted into the infrared at z ∼ 5 − 11, has been proposed as a potential tracer.
Lipatova Veronika, Glover Simon C. O., Klessen Ralf S., Liu Boyuan   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Signatures of very massive stars in the epoch of reionization

Astronomy & Astrophysics
We present ultra-deep (≃20 − 30 hours) rest-frame UV spectroscopy with NIRSpec of two UV-bright galaxies at z ∼ 8.7, CEERS-1019 and CEERS-1025 (Zneb ≃ 0.1 Z⊙), obtained as part of the JWST Cycle 4 SPURS large program.
Marques-Chaves R., Martins F., Schaerer D., Dessauges-Zavadsky M., Palacios A.   +4 more
doaj   +1 more source

Les sites de hauteur en Crète pendant les siècles obscurs

Projets de Paysage, 2010
At the end of the Bronze Age in Crete, a particular phenomenon makes its appearance. In effect, with the disappearing of centralized power and big palaces, the population scatters and leaves sites in lowland or along the coast to the advantage of site in
Nathalie Monio
doaj   +1 more source

Stratigraphy, Crater Size–Frequency Distribution, and Chronology of Selected Areas of Ganymede’s Light and Dark Terrains

The Planetary Science Journal, 2023
The stratigraphy of the largest natural satellite of our solar system, Ganymede, is investigated using available global mosaic (basemap) and high-resolution images. We are focusing on the reconstruction of the formation and tectonic evolution of selected
Namitha Rose Baby, Roland J. Wagner, Katrin Stephan, Thomas Kenkmann   +3 more
doaj   +1 more source