Results 61 to 70 of about 1,465,941 (244)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

De l'usage des Dark Ages en histoire médiévale

, 2017
https://howardwilliamsblog.wordpress.com/2016/06/02/bring-back-the-dark ...
Gautier, Alban
core   +1 more source

Enlightening the dark ages with dark matter

, 2019
Constraints on dark matter annihilation or decay offer unique insights into the nature of dark matter. We illustrate how surveys dedicated to detect the highly redshifted 21 cm signal from the dark ages will offer a new window into properties of particle
Bernal J. L., Chluba, Jens, Short K., Raccanelli, Alvise, Chluba J., Raccanelli A., Verde L., Short, Katie, Verde, Licia, Bernal, José Luis   +9 more
core   +1 more source

The Magnitude of the Dark Ages 21 cm Signal in the Context of Existing Early and Late Time Constraints on ΛCDM

The Astrophysical Journal Letters
The dark ages 21 cm signal is a promising probe of the currently unobserved infant Universe between the formation of the cosmic microwave background around z  ≈ 1100 and the first galaxies around z  ≈ 30.
Harry T. J. Bevins
doaj   +1 more source

A GLIMPSE into the very faint end of the Hβ+[O III]λλ4960,5008 luminosity function at z ∼ 7 – 9 behind Abell S1063

Astronomy & Astrophysics
We used the ultra-deep GLIMPSE JWST/NIRCam survey to constrain the faint end of the [O III]+Hβ luminosity function (LF) down to 1039erg s−1 at z ∼ 7 − 9 behind the lensed Hubble Frontier Field galaxy cluster Abell S1063.
Korber Damien, Chemerynska Iryna, Furtak Lukas J., Atek Hakim, Endsley Ryan, Schaerer Daniel, Chisholm John, Kokorev Vasily, Saldana-Lopez Alberto, Adamo Angela, Muñoz Julian B., Oesch Pascal A., Meyer Romain, Marques-Chaves Rui, Fujimoto Seiji   +14 more
doaj   +1 more source

Francesco Petrarca and the Parameters of Historical Research

Religions, 2012
Although scholars in the first two generations of humanism wrote the histories drawing heavily on ancient Roman sources, Petrarca was the first humanist historian to focuses on the history of ancient Roma.
Ronald Witt
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

The SPHINX public data release

Astronomy & Astrophysics
Context. Low-ionisation state (LIS) metal absorption lines, such as Si II λ1526, are widely used to trace the properties and dynamics of the interstellar medium (ISM) in galaxies.
Mauerhofer Valentin, Blaizot Jérémy, Garel Thibault, Verhamme Anne, Gazagnes Simon, Kerutt Josephine, Michel-Dansac Leo, Parker Kaelee S., Rosdahl Joakim, Saldana-Lopez Alberto, Trebitsch Maxime, Kimm Taysun, Ocvirk Pierre, Teyssier Romain   +13 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Extremely ultraviolet-bright starbursts at the end of cosmic reionization

Astronomy & Astrophysics
We present a study of 27 very UV-bright (−22.0 ≲ MUV ≲ −24.4) star-forming galaxies at z ∼ 6 identified in the Subaru High-z Exploration of Low-Luminosity Quasars (SHELLQs) survey.
Marques-Chaves R., Schaerer D., Dessauges-Zavadsky M., Álvarez-Márquez J., Hashimoto T., Colina L., Inoue A. K., Blanco-Prieto C., Nakazato Y., Costantin L., Arribas S., Bakx T. J. L. C., Ceverino D., Crespo Gómez A., Fudamoto Y., Hagimoto M., Hamada A., Matsuoka Y., Mawatari K., Onoue M., Osone W., Ren Y. W., Sugahara Y., Terui Y., Yoshida N.   +24 more
doaj   +1 more source