Results 111 to 120 of about 6,544,802 (296)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Generation of realistic input parameters for simulating atmospheric point-spread functions at astronomical observatories

The Open Journal of Astrophysics
High-fidelity simulated astronomical images are an important tool in developing and measuring the performance of image-processing algorithms, particularly for high precision measurements of cosmic shear -- correlated distortions of images of distant ...
Claire-Alice Hébert, Joshua E. Meyers, My H. Do, Patricia R. Burchat, LSST Dark Energy Science Collaboration   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Cascading Dark Energy

The Astrophysical Journal
The standard cosmological model is in the midst of a stress test, thanks to the tension between supernova-based measurements of the Hubble constant H _0 and inferences of its values from cosmic microwave background (CMB) anisotropies.
Kazem Rezazadeh, Amjad Ashoorioon, Daniel Grin   +2 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Forecasts on the dark energy anisotropic stress for the esa euclid survey [PDF]

The cosmological constant Λ seems to be a not satisfactory explanation of the late-time accelerated expansion of the Universe, for which a number of experimental evidences exist; therefore, it has become necessary in the last years to consider ...
Fogli, Simone
core  

The Darkness of Dark Matter and Dark Energy

International Journal of Engineering and Applied Sciences (IJEAS), 2018
The visible universemdashincluding Earth, the sun, other stars, and galaxiesmdashis made of protons, neutrons, and electrons bundled together into atoms. Perhaps one of the most surprising discoveries of the 20th century was that this ordinary, or baryonic, matter makes up less than 5 percent of the mass of the universe.
openaire   +1 more source

Higgs dark energy [PDF]

Classical and Quantum Gravity, 2015
We study the classical dynamics of a non-abelian Higgs theory coupled to gravity in an isotropic and homogeneous Universe. For non-minimal coupling, this theory leads to a model of cosmic inflation that is very attractive due to its simplicity and consistency with the latest experimental data.
openaire   +2 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source