Results 91 to 100 of about 500,277 (262)
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Fortschritte der Physik, 2019 AbstractWe study the phenomenology of a recent string construction with a quantum mechanically stable dark energy. A mild supersymmetry protects the vacuum energy but also allows TeV scale superpartner masses. The construction is holographic in the sense that the 4D spacetime is generated from “spacetime pixels” originating from five‐branes wrapped ...
Heckman J. J. +4 more
openaire +3 more sources
The Astrophysical JournalThe standard cosmological model is in the midst of a stress test, thanks to the tension between supernova-based measurements of the Hubble constant H _0 and inferences of its values from cosmic microwave background (CMB) anisotropies.
Kazem Rezazadeh +2 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
Explaining Holographic Dark Energy
Galaxies, 2013 The possible holographic origin of dark energy is investigated. The main existing explanations, namely the UV/IR connection argument of Cohen et al., Thomas’ bulk holography argument, and Ng’s spacetime foam argument, are shown to be not wholly ...
Shan Gao
doaj +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
The Darkness of Dark Matter and Dark Energy
International Journal of Engineering and Applied Sciences (IJEAS), 2018 The visible universemdashincluding Earth, the sun, other stars, and galaxiesmdashis made of protons, neutrons, and electrons bundled together into atoms. Perhaps one of the most surprising discoveries of the 20th century was that this ordinary, or baryonic, matter makes up less than 5 percent of the mass of the universe.
openaire +1 more source
Holographic Dark Information Energy
Entropy, 2011 Landauer’s principle and the Holographic principle are used to derive the holographic information energy contribution to the Universe. Information energy density has increased with star formation until sufficient to start accelerating the expansion of ...
Michael Paul Gough
doaj +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source