Results 81 to 90 of about 500,277 (262)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Demonstration of scissor-cross ionization injection in laser wakefield accelerators

Communications Physics
Laser wakefield acceleration (LWFA) holds great potential in the exploration of the next-generation accelerators and future colliders, in which the injection mechanism plays a crucial role as it directly affects the characteristics of electron ...
Siyu Chen, Guangwei Lu, Xichen Hu, Mingyang Zhu, Minghao Ma, Ming Zeng, Hao Xu, Jia Wang, Mingxuan Wei, Jiao Jia, Zhida Yang, Hanmi Mou, Zhuofan Zhang, Runze Li, Feng liu, Boyuan Li, Min chen, Dazhang Li, Wenchao Yan   +18 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Dark Energy: The Shadowy Reflection of Dark Matter?

Entropy, 2016
In this article, we review a series of recent theoretical results regarding a conventional approach to the dark energy (DE) concept. This approach is distinguished among others for its simplicity and its physical relevance.
Kostas Kleidis, Nikolaos K. Spyrou
doaj   +1 more source

Addressing the high-f problem in pseudo-Nambu–Goldstone boson dark energy models with dark matter–dark energy interaction

European Physical Journal C: Particles and Fields, 2020
We consider a dark energy scenario driven by a scalar field $$\phi $$ ϕ with a pseudo-Nambu–Goldstone boson (pNGB) type potential $$V(\phi )=\mu ^4 \left( 1+ \mathrm{cos}(\phi /f) \right) $$ V ( ϕ ) = μ 4 1 + cos ( ϕ / f ) .
Upala Mukhopadhyay, Avik Paul, Debasish Majumdar   +2 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Generation of realistic input parameters for simulating atmospheric point-spread functions at astronomical observatories

The Open Journal of Astrophysics
High-fidelity simulated astronomical images are an important tool in developing and measuring the performance of image-processing algorithms, particularly for high precision measurements of cosmic shear -- correlated distortions of images of distant ...
Claire-Alice Hébert, Joshua E. Meyers, My H. Do, Patricia R. Burchat, LSST Dark Energy Science Collaboration   +4 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Optimisation of the vertex detector and measurement of Higgs decays to second-generation quarks at the CEPC

Journal of High Energy Physics
The vertex detector is crucial for precision measurements of the Higgs boson at the electron-positron Higgs factory. Benchmarked with H → c c ¯ $$ H\to c\overline{c} $$ and H → s s ¯ $$ H\to s\overline{s} $$ measurements in the ν ν ¯ H $$ \nu \overline ...
Jialin Li, Hao Liang, Kaili Zhang, Yifan Zhu, Jun Guo, Haijun Yang, Manqi Ruan   +6 more
doaj   +1 more source