Results 51 to 60 of about 468,012 (314)

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

open access: yesFEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera   +4 more
wiley   +1 more source

Determination of resonances in Gamow window for 12C+12C fusion reaction via thick-target inverse kinematics method

open access: yesPhysics Letters B
The 12C+12C fusion reaction at deep subbarrier energies is important for understanding the carbon burning process in massive star and explosive binary systems.
Weike Nan   +19 more
doaj   +1 more source

Changes in Microbial Energy Metabolism Measured by Nanocalorimetry during Growth Phase Transitions

open access: yesFrontiers in Microbiology, 2018
Calorimetric measurements of the change in heat due to microbial metabolic activity convey information about the kinetics, as well as the thermodynamics, of all chemical reactions taking place in a cell.
Alberto Robador   +11 more
doaj   +1 more source

Dark energy and dark matter haloes [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society, 2005
16 p., 11 fig.; replaced with revised version, accepted for publication in MNRAS; corrected error (w=-1.5 halo mass function now agrees with Jenkins et al.
Andrew R. Zentner   +4 more
openaire   +3 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Dipolar dark matter and dark energy [PDF]

open access: yesPhysical Review D, 2009
In previous work [L. Blanchet and A. Le Tiec, Phys. Rev. D 78, 024031 (2008)], a model of dark matter and dark energy based on the concept of gravitational polarization was investigated. This model was shown to recover the concordance cosmological scenario (Lambda-CDM) at cosmological scales, and the phenomenology of the modified Newtonian dynamics ...
Blanchet, Luc, Le Tiec, Alexandre
openaire   +3 more sources

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Coupling q-Deformed Dark Energy to Dark Matter

open access: yesAdvances in High Energy Physics, 2016
We propose a novel coupled dark energy model which is assumed to occur as a q-deformed scalar field and investigate whether it will provide an expanding universe phase. We consider the q-deformed dark energy as coupled to dark matter inhomogeneities.
Emre Dil
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

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