Results 61 to 70 of about 468,012 (314)

Dark Matter and Dark Energy in the Universe

Bibechana, 2014
Cosmological and astronomical observations predict that the present Universe is passing through an accelerating phase of expansion. The Universe emerged out of an exponential phase in the very early Universe.
BC Paul
doaj   +3 more sources

Quantum Haplodynamics, Dark Matter, and Dark Energy

Advances in High Energy Physics, 2014
In quantum haplodynamics (QHD) the weak bosons, quarks, and leptons are bound states of fundamental constituents, denoted as haplons. The confinement scale of the associated gauge group SU(2)h is of the order of Λh≃0.3 TeV.
Harald Fritzsch, Joan Solà
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Improved Tomographic Binning of 3 × 2 pt Lens Samples: Neural Network Classifiers and Optimal Bin Assignments

The Astrophysical Journal, 2023
Large imaging surveys, such as the Legacy Survey of Space and Time, rely on photometric redshifts and tomographic binning for 3 × 2 pt analyses that combine galaxy clustering and weak lensing.
Irene Moskowitz, Eric Gawiser, Abby Bault, Adam Broussard, Jeffrey A. Newman, Joe Zuntz, The LSST Dark Energy Science Collaboration   +6 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

ELECTROMAGNETIC DARK ENERGY [PDF]

International Journal of Modern Physics D, 2008
We introduce a new model for dark energy in the Universe in which a small cosmological constant is generated by ordinary electromagnetic vacuum energy. The corresponding virtual photons exist at all frequencies but switch from a gravitationally active phase at low frequencies to a gravitationally inactive phase at higher frequencies via a Ginzburg ...
Christian Beck, Michael C. Mackey
openaire   +4 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Astrometric Redshifts of Supernovae

The Astrophysical Journal
Differential Chromatic Refraction (DCR) is caused by the wavelength dependence of our atmosphere’s refractive index, which shifts the apparent positions of stars and galaxies and distorts their shapes depending on their spectral energy distributions ...
Jaemyoung (Jason) Lee, Masao Sako, Richard Kessler, Alex I. Malz, The LSST Dark Energy Science Collaboration   +4 more
doaj   +1 more source

DARK ENERGY, WITH SIGNATURES [PDF]

International Journal of Modern Physics D, 2010
We propose a class of simple dark energy models which predict a late-time dark radiation component and a distinctive time-dependent equation of state w(z) for redshift z < 3. The dark energy field can be coupled strongly enough to standard model particles to be detected in colliders, and the model requires only modest additional particle content ...
Sourish Dutta, Stephen D. H. Hsu, Robert J. Scherrer   +2 more
openaire   +3 more sources

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source