Results 71 to 80 of about 9,248,821 (298)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Proposed Dark Energy Experiment using Fullerenes

Physics Procedia, 2012
AbstractA dark energy experiment is proposed, based on the dark energy research funded by the U.S. Department of Energy (DOE), Office of Science. The experiment would replicate the conditions of deep space; i.e., ultra-vacuum, isolation from the Earth's magnetic field, cryogenic temperatures, and an isotropic environment.
openaire   +1 more source

Inflationary generalized Chaplygin gas and dark energy in light of the Planck and BICEP2 experiments [PDF]

Physical Review D, 2014
12 pages, Latex style, 7 eps figures, 1 ...
Dinda, Bikash R, Kumar, Sumit, Sen, Anjan A.   +2 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Constraining dark energy using real and mock galaxy surveys [PDF]

, 2009
In this thesis, we study how dark energy may be constrained by measurements of large-scale clustering in future galaxy surveys, and through the imprint of a time-varying large-scale potential on the CMB (the integrated Sachs-Wolfe effect).
CAI, YANCHUAN
core  

The Dark Energy Survey:more than dark energy - an overview [PDF]

, 2016
This overview paper describes the legacy prospect and discovery potential of the Dark Energy Survey (DES) beyond cosmological studies, illustrating it with examples from the DES early data.
Diehl, H. T., Reed, S. L., Gerdes, D. W., Benoit-Levy, A, Bertin, E., Thaler, J, Sheldon, E., Swanson, M, Nichol, R., Burke, D., Maraston, C, Rozo, E., Li, T. S., Gruen, D, Zuntz, Joseph, Caminha, GB, Bechtol, K., T Abbot (14857732), Walker, A. R., Conselice, C, Bridle, Sarah, Gerdes, DW, D Andrea, CB, Goldstein, D. A., Smith, RC, Caminha, G., Romer, A. K., Foley, R., K Bechtol (7769357), Burke, DL, Kron, R., Carlsen, J, Peiris, HV, Ostrovski, F., Bernstein, G.M., Swanson, M., Thomas, R. C., Ogando, R., Brooks, D., Thaler, J., Carrasco-Kind, M, Crocce, M., Merson, A., Goldstein, DA, Whiteway, L, Capozzi, D, Bridle, S., Collett, T, Foley, RJ, Goldstein, D., Abbott, T., Kessler, R, Nichol, R. C., Crocce, M, Mohr, JJ, E Bertin (7793387), Bonnett, C., Marshall, J. L., King, A., Etherington, J., Amara, A, Li, T., Peiris, H., Roodman, A, Carnero-Rosell, A., Lahav, O, Gerdes, D., James, D. J., Zhang, Y, Peoples, J, Cunha, C. E., Evrard, A. E., Gaztanaga, E., Kirk, D., Amara, A., Papadopoulos, A, Naidoo, K., Sevilla-Noarbe, I, Lima, M, Thomas, D., Evrard, AE, Sadeh, I, Nord, B., Plazas, A., Evrard, A., A Amara (16231271), Melchior, Peter M, Allam, S., Naidoo, K, Estrada, J, Fosalba, P, Wechsler, RH, Frieman, J, Palmese, A, Sullivan, M., Castander, FJ, Peiris, H. V., Makler, M., Miquel, R, Plazas, AA, Castander, F., Plazas, A. A., Jouvel, S, da Costa, L., Fabbri, J, Davis, T. M., Fosalba, P., Nord, B, Soumagnac, M, Gruen, D., Bertin, E, Etherington, J, Drlica-Wagner, A., Buckley-Geer, E, Kuropatkin, N., Bacon, D., Kirk, D, Miquel, R., Soares-Santos, M, Burke, D. L., Carlsen, J., Ogando, R, Carollo, M, da Costa, LN, Miller, CJ, Rykoff, E. S., J Blazek (12492481), Costa, L. N. da, Conselice, Christopher J., Dietrich, JP, Tarle, G., Wester, W., Wilcox, H., Brunner, RJ, Vikram, V., Zuntz, J, others (6644544), da Costa, L. N., Miller, C., Scarpine, V, Brunner, R., Fabbri, J., Marshall, J., Dietrich, J. P., Vikram, V, Dodelson, S, Banerji, M., Estrada, J., James, D., Lin, H., Thomas, D, Dietrich, J., Wechsler, R., Percival, W. J., Lin, H, Abbott, T, King, A, Melchior, P., Soares-Santos, M., Kuropatkin, N, Zuntz, J., Neilsen, E, Marshall, JL, Weller, J., Nichol, RC, James, DJ, Jain, B., Drlica-Wagner, A, McMahon, R., Buckley-Geer, E., Ross, A, Garcia-Bellido, J, A Benoit-Lévy (16231238), Reed, S., Walker, A., Morice-Atkinson, X., Santiago, B., Gruendl, RA, Carnero-Rosell, A, Blazek, J., Bernstein, GM, D'Andrea, C., Hartley, W., Zhang, Y., Balbinot, E., Aleksic, J, G M Bernstein (16038710), Weller, J, Brunner, R. J., Romer, A., Rykoff, E., McMahon, R. G., Gaztanaga, E, Reed, SL, Gruendl, R., Maraston, C., Tarle, G, Wester, W, Jain, B, J Aleksic (16231268), Kuehn, K, Vieira, JD, Bacon, D, Santiago, B, Palmese, A., Abdalla, F.B., Walker, AR, Bernstein, G., Kathy Romer (4460893), Abdalla, F., Carretero, J, Romer, AK, The Dark Energy Survey Collaboration (16231277), D'Andrea, CB, Diehl, HT, Kessler, R., Rykoff, ES, Frieman, J., Giannantonio, T., Manera, M., Abdalla, FB, Sako, M., Soumagnac, M., Vieira, J., Sadeh, I., Gutierrez, G., E Balbinot (7793279), Maia, M., Carretero, J., Benoit-Levy, A., Jouvel, S., Guarnieri, P., Clerkin, L., Vieira, J. D., Banerji, M, Carrasco-Kind, M., Smith, M, Lahav, O., Flaugher, B, Hartley, W, Blazek, J, Yanny, B, Diehl, H., Abdalla, F. B., Smith, M., Martini, P, McMahon, RG, Refregier, A., D Bacon (16039940), Garcia-Bellido, J., Sevilla-Noarbe, I., Flaugher, B., Tucker, D., S Allam (7793276), Sanchez, C., Caminha, G. B., Neilsen, E., Refregier, A, Wilcox, H, Bridle, S, Sako, M, Davis, T., Mohr, J., Conselice, C., Suchyta, E., Bonnett, C, Sheldon, E, C Bonnett (16231274), Wechsler, R. H., Whiteway, L., Melchior, P, Percival, WJ, Schubnell, M, Desai, S., Tucker, D, Li, TS, Martini, P., Manera, M, Maia, MAG, Bechtol, K, Makler, M, Collett, T., Ostrovski, F, D'Andrea, C. B., Sobreira, F., Rozo, E, Finley, D., Guarnieri, P, F B Abdalla (16231265), Carollo, M., Suchyta, E, Honscheid, K, Sanchez, E, Kron, R, Sanchez, C, Schubnell, M., Sanchez, E., Thomas, RC, Peoples, J., Sobreira, F, Jeltema, T., Percival, W., Castander, F. J., Scarpine, V., Dodelson, S., Smith, R. C., Balbinot, E, Roodman, A., Cunha, CE, Morice-Atkinson, X, Giannantonio, T, Merson, A, Thomas, R., Yanny, B., Smith, R., M Banerji (9209765), Foley, R. J., Gruendl, R. A., Lima, M., Sullivan, M, Papadopoulos, A., Brooks, D, Doel, P, Finley, DA, Bernstein, G. M., Aleksic, J., Ross, A., Davis, TM, Doel, P., Miller, C. J., Honscheid, K., Mohr, J. J., Desai, S, Gutierrez, G, Capozzi, D., Collaboration, Dark Energy Survey, Maia, M. A. G., Allam, S, Dark Energy Survey Collaboration, Cunha, C., Jeltema, T, Finley, D. A., Clerkin, L, Kuehn, K.   +343 more
core   +1 more source

A comprehensive study of low-energy response for xenon-based dark matter experiments [PDF]

Journal of Physics G: Nuclear and Particle Physics, 2017
Abstract We report a comprehensive study of the energy response to low-energy recoils in dual-phase xenon-based dark matter experiments. A recombination model is developed to explain the recombination probability as a function of recoil energy at zero field and non-zero field.
Wang, L., Mei, D. -M.
openaire   +2 more sources

Transmon Qubit constraints on dark matter-nucleon scattering

Journal of High Energy Physics
We recently pointed out that power measurements of single quasiparticle devices can be used to detect dark matter. These devices have the lowest known energy thresholds, far surpassing standard direct detection experiments, requiring energy deposition ...
Anirban Das, Noah Kurinsky, Rebecca K. Leane   +2 more
doaj   +1 more source

Indirect searches for dark matter bound state formation and level transitions

SciPost Physics, 2020
Indirect searches for dark matter (DM) have conventionally been applied to the products of DM annihilation or decay. If DM couples to light force carriers, however, it can be captured into bound states via dissipation of energy that may yield ...
Iason Baldes, Francesca Calore, Kalliopi Petraki, Vincent Poireau, Nicholas L. Rodd
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source