Results 61 to 70 of about 363,778 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spectroscopic Needs for Imaging Dark Energy Experiments: Photometric Redshift Training and Calibration

, 2013
Large sets of objects with spectroscopic redshift measurements will be needed for imaging dark energy experiments to achieve their full potential, serving two goals:_training_, i.e., the use of objects with known redshift to develop and optimize photometric redshift algorithms; and_calibration_, i.e., the characterization of moments of redshift (or ...
Newman, J., Abate, A., Abdalla, F., Allam, S., Allen, S., Ansari, R., Bailey, S., Barkhouse, W., Beers, T., Blanton, M., Brodwin, M., Brownstein, J., Brunner, R., Carrasco-Kind, M., Cervantes-Cota, J., Chisari, E., Colless, M., Comparat, J., Coupon, J., Cheu, E., Cunha, C., de la Macorra, A., Dell'Antonio, I., Frye, B., Gawiser, E., Gehrels, N., Grady, K., Hagen, A., Hall, P., Hearin, A., Hildebrandt, H., Hirata, C., Ho, S., Honscheid, K., Huterer, D., Ivezic, Z., Kneib, J. -P., Kruk, J., Lahav, O., Mandelbaum, R., Marshall, J., Matthews, D., Ménard, B., Miquel, R., Moniez, M., Moos, W., Moustakas, J., Papovich, C., Peacock, J., Park, C., Rhodes, J., Ricol, J-S., Sadeh, I., Slozar, A., Schmidt, S., Stern, D., Tyson, T., von der Linden, A., Wechsler, R., Wood-Vasey, W., Zentner, A.   +60 more
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Transmon Qubit constraints on dark matter-nucleon scattering

Journal of High Energy Physics
We recently pointed out that power measurements of single quasiparticle devices can be used to detect dark matter. These devices have the lowest known energy thresholds, far surpassing standard direct detection experiments, requiring energy deposition ...
Anirban Das, Noah Kurinsky, Rebecca K. Leane   +2 more
doaj   +1 more source

Solar-System experiments in the search for dark energy and dark matter

Physical Review D
32 pages, 4 figures, 12 ...
openaire   +2 more sources

A comprehensive study of low-energy response for xenon-based dark matter experiments [PDF]

Journal of Physics G: Nuclear and Particle Physics, 2017
30 pages and 21 ...
Wang, L., Mei, D. -M.
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Dark tridents at off-axis liquid argon neutrino detectors

Journal of High Energy Physics, 2019
We present dark tridents, a new channel for exploring dark sectors in short-baseline neutrino experiments. Dark tridents are clean, distinct events where, like neutrino tridents, the scattering of a very weakly coupled particle leads to the production of
André de Gouvêa, Patrick J. Fox, Roni Harnik, Kevin J. Kelly, Yue Zhang   +4 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Screened Scalar Fields in the Laboratory and the Solar System

Universe
The last few decades have provided abundant evidence for physics beyond the two standard models of particle physics and cosmology. As is now known, the by far largest part of our universe’s matter/energy content lies in the ‘dark’, and consists of dark ...
Hauke Fischer, Christian Käding, Mario Pitschmann   +2 more
doaj   +1 more source