Results 81 to 90 of about 9,248,821 (298)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

The Tolman-Oppenheimer-Volkoff equations in unified models of dark matter and dark energy [PDF]

open access: yes, 2022
In this thesis we will work on scalar field models for dark matter and dark energy. In particular, we will study unified haloes by means of a static and spherically symmetric metric which leads to the anisotropic Tolman-Oppenheimer-Volkoff (TOV) equation.
Bassi, Alberto
core  

The Quantum Triple-Slit Experiment and Dark Energy

open access: yesOpen Journal of Microphysics, 2017
The experimental discovery of looped light in a three-slit experiment is interpreted as a strong justification of the Peano-Hilbert spacetime model. This in turn entails the existence of a dark energy density in full agreement with previous analysis as well as accurate measurements and observations.
openaire   +2 more sources

Screened Scalar Fields in the Laboratory and the Solar System

open access: yesUniverse
The last few decades have provided abundant evidence for physics beyond the two standard models of particle physics and cosmology. As is now known, the by far largest part of our universe’s matter/energy content lies in the ‘dark’, and consists of dark ...
Hauke Fischer   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Dark tridents at off-axis liquid argon neutrino detectors

open access: yesJournal of High Energy Physics, 2019
We present dark tridents, a new channel for exploring dark sectors in short-baseline neutrino experiments. Dark tridents are clean, distinct events where, like neutrino tridents, the scattering of a very weakly coupled particle leads to the production of
André de Gouvêa   +4 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Nuclear production and analytic attenuation of energetic MeV solar dark matter

open access: yesPhysics Letters B
We propose a solar production mechanism of MeV dark matter to overcome the energy threshold in direct detection experiments. In particular, the proton and deuteron fusion to 3He of the pp chain that produces energetic neutrino and gamma photon with 5.5 ...
Shao-Feng Ge   +3 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy