Results 81 to 90 of about 363,778 (266)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Direct deflection of Millicharged radiation

Journal of High Energy Physics
Millicharged particles are generic in theories of dark sectors. A cosmic or local abundance of them may be produced by the early universe, stellar environments, or the decay or annihilation of dark matter/dark energy.
Asher Berlin, Surjeet Rajendran, Harikrishnan Ramani, Erwin H. Tanin   +3 more
doaj   +1 more source

An explanation of one-loop induced h→μτ decay

Physics Letters B, 2016
We discuss a possibility to explain the excess of h→μτ at one-loop level. We introduce three generations of vector-like lepton doublet L′ and two singlet scalars S1,2 which are odd under Z2, while all the standard model fields are even under this ...
Seungwon Baek, Takaaki Nomura, Hiroshi Okada   +2 more
doaj   +1 more source

UP TO 100,000 RELIABLE STRONG GRAVITATIONAL LENSES IN FUTURE DARK ENERGY EXPERIMENTS [PDF]

The Astrophysical Journal, 2014
The Euclid space telescope will observe ~10^5 strong galaxy-galaxy gravitational lens events in its wide field imaging survey over around half the sky, but identifying the gravitational lenses from their observed morphologies requires solving the difficult problem of reliably separating the lensed sources from contaminant populations, such as tidal ...
openaire   +2 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Solar neutrinos in cryogenic detectors

European Physical Journal C: Particles and Fields
Coherent elastic neutrino-nucleus scattering (CE $$\nu $$ ν NS) poses an irreducible background in the search for dark matter-nucleus elastic scatterings, which is commonly known as the neutrino floor.
A. Bento, A. Bertolini, L. Canonica, S. Di Lorenzo, F. Dominsky, N. Ferreiro Iachellini, D. Fuchs, A. Garai, D. Hauff, A. Langenkämper, M. Mancuso, B. Mauri, F. Petricca, F. Pröbst, F. Pucci, L. Stodolsky   +15 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source