Results 101 to 110 of about 738,435 (332)

Interacting two-component fluid models with varying EoS parameter

open access: yes, 2014
In this paper, we consider Universe filled with two-component fluid. We study two different models. In the first model we assume barotropic fluid with the linear equation of state as the first component of total fluid.
Kahya, E. O.   +2 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Dark Matter from freeze-in and its inhomogeneities

open access: yesJournal of High Energy Physics, 2023
We consider generic freeze-in processes for generation of Dark Matter, together with the consequent re-thermalization of the Standard Model fluid. We find that Dark Matter inherits the Standard Model adiabatic inhomogeneities on the cosmological scales ...
Alessandro Strumia
doaj   +1 more source

Expansionfree Fluid Evolution and Skripkin Model in f(R) Theory

open access: yes, 2011
We consider the modified $f(R)$ theory of gravity whose higher order curvature terms are interpreted as a gravitational fluid or dark source. The gravitational collapse of a spherically symmetric star, made up of locally anisotropic viscous fluid, is ...
H. RIZWANA KAUSAR   +7 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Invariant Solutions and Nonlinear Self-Adjointness of the Two-Component Chaplygin Gas Equation

open access: yesDiscrete Dynamics in Nature and Society, 2019
In this paper, the Lie group method is performed on a special dark fluid, the Chaplygin gas, which describes both dark matter and dark energy in the present universe.
Ben Gao, Yanxia Wang
doaj   +1 more source

Three fluid cosmological model using Lie and Noether symmetries

open access: yes, 2011
We employ a three fluid model in order to construct a cosmological model in the Friedmann Robertson Walker flat spacetime, which contains three types of matter dark energy, dark matter and a perfect fluid with a linear equation of state.
Paliathanasis, Andronikos   +1 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Exotic Compact Objects with Two Dark Matter Fluids

open access: yesThe Astrophysical Journal, 2023
The generic properties of compact objects made of two different fluids of dark matter are studied in a scale-invariant approach. We investigate compact objects with a core–shell structure, where the two fluids are separated, and with mixed dark matter ...
Marie Cassing   +3 more
doaj   +1 more source

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