Results 91 to 100 of about 1,667,560 (344)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Dark Matter Burners [PDF]

The Astrophysical Journal, 2007
4 pages, 4 figures, emulateapj.cls; Astrophysical Journal Letters ...
Moskalenko, Igor V., /Stanford U., HEPL, Wai, Lawrence L.   +2 more
openaire   +3 more sources

Constraints on leptophilic dark matter from the AMS-02 experiment

, 2017
The annihilation of dark matter particles in the galactic halo of the Milky Way may lead to cosmic ray signatures that can be probed by the AMS-02 experiment, which has measured the composition and fluxes of charged cosmic rays with unprecedented ...
Cavasonza, Leila Ali, Gast, Henning, Krämer, Michael, Pellen, Mathieu, Schael, Stefan   +4 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Muonphilic dark matter explanation of gamma-ray galactic center excess: a comprehensive analysis

Journal of High Energy Physics, 2022
The Galactic center gamma-ray excess (GCE) is a long-standing unsolved problem. One of candidate solutions, the dark matter (DM) annihilation, has been recently tested with other astrophysical observations, such as AMS-02 electron-positron spectra, Fermi
Murat Abdughani, Yi-Zhong Fan, Chih-Ting Lu, Tian-Peng Tang, Yue-Lin Sming Tsai   +4 more
doaj   +1 more source

Gravitational Waves in Einstein-Cartan Theory: On the Effects of Dark Matter Spin Tensor [PDF]

, 2022
E. Elizalde, F. Izaurieta, C. Riveros, G. Salgado, O. Valdivia   +4 more
openalex   +1 more source

Composite Millicharged Dark Matter

, 2013
We study a composite millicharged dark matter model. The dark matter is in the form of pion-like objects emerging from a higher scale QCD-like theory.
Kouvaris, Chris
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

CYG $$\nu $$ ν S: detecting solar neutrinos with directional gas time projection chambers

European Physical Journal C: Particles and Fields
Cygnus is a proposed global network of large-scale gas time projection chambers (TPCs) with the capability of directionally detecting nuclear and electron recoils at $$\gtrsim $$ ≳ keV energies.
Chiara Lisotti, Ciaran A. J. O’Hare, Elisabetta Baracchini, Victoria U. Bashu, Lindsey J. Bignell, Ferdos Dastgiri, Majd Ghrear, Gregory J. Lane, Lachlan J. McKie, Peter C. McNamara, Samuele Torelli   +10 more
doaj   +1 more source

How Cold is Cold Dark Matter?

, 2014
If cold dark matter consists of particles, these must be non-interacting and non-relativistic by definition. In most cold dark matter models however, dark matter particles inherit a non-vanishing velocity dispersion from interactions in the early ...
Armendariz-Picon, Cristian, Neelakanta, Jayanth T.   +1 more
core   +1 more source