Results 71 to 80 of about 217,256 (267)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Physics Letters B, 2003 Velocity-dependent interactions in a fundamental-string dominated universe lead quite naturally, with reasonable assumptions on initial conditions, to an accelerating expanding universe without assuming the existence of a cosmological constant. This result also holds generically for a universe dominated by moving extremal black holes, owing to a ...
openaire +2 more sources
CYG $$\nu $$ ν S: detecting solar neutrinos with directional gas time projection chambers
European Physical Journal C: Particles and FieldsCygnus is a proposed global network of large-scale gas time projection chambers (TPCs) with the capability of directionally detecting nuclear and electron recoils at $$\gtrsim $$ ≳ keV energies.
Chiara Lisotti +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Interacting dark matter disguised as warm dark matter
Physical Review D, 2002 14 pages, 5 figures, to appear in ...
Boehm, Celine +3 more
openaire +2 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Charmed baryon decays: SU(3) F breaking and CP violation
Journal of High Energy PhysicsWe present a comprehensive study of anti-triplet charmed baryon decays into octet baryons and pseudoscalar mesons using the SU(3) F flavor symmetry framework.
Chang Yang, Xiao-Gang He, Chia-Wei Liu
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
VIS - Nordic Journal for Artistic ResearchDarkness Matters displays historic lightscapes, specifically at night, from petroglyphs to James Webb Telescope images. The exposition constructs a sort of cabinet of curiosities and wants to take the visitor on a private journey to a virtual exhibition space to re-embrace the endeavors under and around the nocturnal vault, an underrepresented micro ...
openaire +2 more sources
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source