Results 71 to 80 of about 214,465 (268)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Muonphilic dark matter explanation of gamma-ray galactic center excess: a comprehensive analysis

Journal of High Energy Physics, 2022
The Galactic center gamma-ray excess (GCE) is a long-standing unsolved problem. One of candidate solutions, the dark matter (DM) annihilation, has been recently tested with other astrophysical observations, such as AMS-02 electron-positron spectra, Fermi
Murat Abdughani, Yi-Zhong Fan, Chih-Ting Lu, Tian-Peng Tang, Yue-Lin Sming Tsai   +4 more
doaj   +1 more source

DARKNESS MATTERS

VIS - Nordic Journal for Artistic Research
Darkness Matters displays historic lightscapes, specifically at night, from petroglyphs to James Webb Telescope images. The exposition constructs a sort of cabinet of curiosities and wants to take the visitor on a private journey to a virtual exhibition space to re-embrace the endeavors under and around the nocturnal vault, an underrepresented micro ...
openaire   +2 more sources

Interacting dark matter disguised as warm dark matter

Physical Review D, 2002
14 pages, 5 figures, to appear in ...
Boehm, Celine, Riazuelo, Alain, Hansen, Steen H., Schaeffer, Richard   +3 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

CYG $$\nu $$ ν S: detecting solar neutrinos with directional gas time projection chambers

European Physical Journal C: Particles and Fields
Cygnus is a proposed global network of large-scale gas time projection chambers (TPCs) with the capability of directionally detecting nuclear and electron recoils at $$\gtrsim $$ ≳ keV energies.
Chiara Lisotti, Ciaran A. J. O’Hare, Elisabetta Baracchini, Victoria U. Bashu, Lindsey J. Bignell, Ferdos Dastgiri, Majd Ghrear, Gregory J. Lane, Lachlan J. McKie, Peter C. McNamara, Samuele Torelli   +10 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Charmed baryon decays: SU(3) F breaking and CP violation

Journal of High Energy Physics
We present a comprehensive study of anti-triplet charmed baryon decays into octet baryons and pseudoscalar mesons using the SU(3) F flavor symmetry framework.
Chang Yang, Xiao-Gang He, Chia-Wei Liu
doaj   +1 more source

Dark branes for dark matter

Physical Review D
We propose a setup for the origin of dark matter based on spacetime with a warped extra dimension and three branes: the Planck brane, the TeV brane, at a (few) TeV scale ρT, and a dark brane, at a (sub-)GeV scale ρ1≲100  GeV≪ρT. The Standard Model (SM) is localized in the TeV brane, thus solving the Higgs hierarchy problem, while the dark matter χ, a ...
Fotis Koutroulis, Eugenio Megías, Stefan Pokorski, Mariano Quirós   +3 more
openaire   +2 more sources