Results 91 to 100 of about 1,630,167 (297)

CYG $$\nu $$ ν S: detecting solar neutrinos with directional gas time projection chambers

European Physical Journal C: Particles and Fields
Cygnus is a proposed global network of large-scale gas time projection chambers (TPCs) with the capability of directionally detecting nuclear and electron recoils at $$\gtrsim $$ ≳ keV energies.
Chiara Lisotti, Ciaran A. J. O’Hare, Elisabetta Baracchini, Victoria U. Bashu, Lindsey J. Bignell, Ferdos Dastgiri, Majd Ghrear, Gregory J. Lane, Lachlan J. McKie, Peter C. McNamara, Samuele Torelli   +10 more
doaj   +1 more source

Muonphilic dark matter explanation of gamma-ray galactic center excess: a comprehensive analysis

Journal of High Energy Physics, 2022
The Galactic center gamma-ray excess (GCE) is a long-standing unsolved problem. One of candidate solutions, the dark matter (DM) annihilation, has been recently tested with other astrophysical observations, such as AMS-02 electron-positron spectra, Fermi
Murat Abdughani, Yi-Zhong Fan, Chih-Ting Lu, Tian-Peng Tang, Yue-Lin Sming Tsai   +4 more
doaj   +1 more source

Decaying Dark Matter from Dark Instantons

, 2010
We construct an explicit, TeV-scale model of decaying dark matter in which the approximate stability of the dark matter candidate is a consequence of a global symmetry that is broken only by instanton-induced operators generated by a non-Abelian dark ...
Christopher D. Carone, E. W. Kolb, Joshua Erlich, Reinard Primulando, V. A. Kuzmin, V. A. Kuzmin   +5 more
core   +1 more source

Dark branes for dark matter

Physical Review D
We propose a setup for the origin of dark matter based on spacetime with a warped extra dimension and three branes: the Planck brane, the TeV brane, at a (few) TeV scale ρT, and a dark brane, at a (sub-)GeV scale ρ1≲100  GeV≪ρT. The Standard Model (SM) is localized in the TeV brane, thus solving the Higgs hierarchy problem, while the dark matter χ, a ...
Fotis Koutroulis, Eugenio Megías, Stefan Pokorski, Mariano Quirós   +3 more
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Constraints on leptophilic dark matter from the AMS-02 experiment

, 2017
The annihilation of dark matter particles in the galactic halo of the Milky Way may lead to cosmic ray signatures that can be probed by the AMS-02 experiment, which has measured the composition and fluxes of charged cosmic rays with unprecedented ...
Cavasonza, Leila Ali, Gast, Henning, Krämer, Michael, Pellen, Mathieu, Schael, Stefan   +4 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Composite Millicharged Dark Matter

, 2013
We study a composite millicharged dark matter model. The dark matter is in the form of pion-like objects emerging from a higher scale QCD-like theory.
Kouvaris, Chris
core   +1 more source

Dark group: dark energy and dark matter [PDF]

Physics Letters B, 2004
We study the possibility that a dark group, a gauge group with particles interacting with the standard model particles only via gravity, is responsible for containing the dark energy and dark matter required by present day observations. We show that it is indeed possible and we determine the constrains for the dark group.
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source