Results 111 to 120 of about 214,465 (268)

Ultrafast Time-Integrated Diagnosis of Laser-Heated Deuterium Ions in Dense Plasma via Fusion Neutron Spectra

Ultrafast Science
The ultrafast time-integrated diagnosis of ions plays a vital role in high-energy-density physics research. However, it is extremely challenging to measure in experiment.
Jie Feng, Hao Xu, Mingxuan Wei, Mingyang Zhu, Xichen Hu, Bingzhan Shi, Fuyuan Wu, Weijun Zhou, Wenchao Yan, Guoqiang Zhang, Jinguang Wang, Yifei Li, Xin Lu, Liming Chen   +13 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Revisiting μ-e conversion in R-parity violating SUSY

Journal of High Energy Physics
The μ-e conversion process is one of the most powerful ways to test lepton-flavor-violating (LFV) interactions involving charged leptons. The standard model with massive neutrinos predicts an extremely low rate for μ-e conversion, making this process an ...
Yu-Qi Xiao, Xiao-Gang He, Hong-Yi Niu, Rong-Rong Zhang   +3 more
doaj   +1 more source

Dark-Matter–Electron Detectors for Dark-Matter–Nucleon Interactions

Physical Review Letters
In a seminal paper now a decade old, it was shown that dark-matter detectors geared at probing interactions with nucleons could also be used to probe dark-matter interactions with electrons. In this Letter, we show that new detector concepts designed to probe dark-matter–electron interactions at low masses can similarly be used to probe new parameter ...
Sinéad M. Griffin, Guy Daniel Hadas, Yonit Hochberg, Katherine Inzani, Benjamin V. Lehmann   +4 more
openaire   +3 more sources

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Transverse Oscillation of Prominence and Filament Induced by an Extreme-ultraviolet Wave from the Far Side of the Sun

The Astrophysical Journal
In this paper, we report our multi-angle observations of the transverse oscillation of a prominence and a filament induced by an EUV wave originating from the far side of the Sun on 2014 September 1. The prominence oscillation was simultaneously observed
Yanjie Zhang, Qingmin Zhang, De-chao Song, Haisheng Ji   +3 more
doaj   +1 more source

Source Count Distribution of Fermi LAT Gamma-Ray Blazars Using Novel Nonparametric Methods

Universe
We utilized a sample from the Fermi-LAT 14-year Source Catalog by adjusting the flux detection threshold, enabling us to derive the intrinsic source count distribution dN/dF25 of extragalactic blazars using nonparametric, unbinned methods developed by ...
Xuhang Yin, Houdun Zeng
doaj   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source