Results 51 to 60 of about 1,630,167 (297)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
SciPost Physics ReviewsWe review observational, experimental and theoretical results related to Dark Matter.
Marco Cirelli +2 more
openaire +2 more sources
Multiple Gamma Lines from Semi-Annihilation [PDF]
, 2012 Hints in the Fermi data for a 130 GeV gamma line from the galactic center have ignited interest in potential gamma line signatures of dark matter. Explanations of this line based on dark matter annihilation face a parametric tension since they often rely
D'Eramo, Francesco +2 more
core +2 more sources
Physical Review D, 1992 A very weakly coupled scalar field with mass $m$ and initial vacuum expectation value $V$ will provide enough mass to close the universe provided $V\simeq (3\times 10^8\gev)(100\gev/m)^{1/4}$. We discuss possible models in which such a field could arise.
Rangarajan, R., Srednicki, M.
openaire +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Getting the astrophysics and particle physics of dark matter out of next-generation direct detection experiments [PDF]
, 2010 The next decade will bring massive new data sets from experiments of the direct detection of weakly interacting massive particle (WIMP) dark matter. The primary goal of these experiments is to identify and characterize the dark-matter particle species ...
A. M. Szelc +2 more
core +2 more sources
Cryptobaryonic Dark Matter [PDF]
Physical Review Letters, 2005 It is proposed that dark matter could consist of compressed collections of atoms (or metallic matter) encapsulated into, for example, 20 cm big pieces of a different phase. The idea is based on the assumption that there exists at least one other phase of the vacuum degenerate with the usual one.
Froggatt, C. D., Nielsen, H. B.
openaire +3 more sources
Journal of High Energy Physics, 2020 Abstract We introduce leak-in dark matter, a novel out-of-equilibrium origin for the dark matter (DM) in the universe. We provide a comprehensive and unified discussion of a minimal, internally-thermalized, hidden sector populated from an out-of-equilibrium, feeble connection to the hotter standard model (SM) sector.
Evans, Jared +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source