Results 41 to 50 of about 217,256 (267)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Unexpected major geomagnetic storm caused by faint eruption of a solar trans-equatorial flux rope
Nature CommunicationsSome geomagnetic storms’ solar origins are ambiguous, making them hard to predict. On March 23, 2023, a severe geomagnetic storm occurred, however, forecasts based on remote-sensing observations failed to predict it.
Weilin Teng +3 more
doaj +1 more source
An Investigation of the Loop Oscillations after a Solar Flare
UniverseWe study the loop oscillations after a solar flare on 19 January 2023, in the active region N11E40 3196, which is well observed by the SDO/AIA. After tracing the loop position and fitting, we find that the loop oscillations have a period between 3 and 9 ...
Jun Xu +5 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
SciPost Physics ReviewsWe review observational, experimental and theoretical results related to Dark Matter.
Marco Cirelli +2 more
openaire +2 more sources
Physical Review D, 1992 A very weakly coupled scalar field with mass $m$ and initial vacuum expectation value $V$ will provide enough mass to close the universe provided $V\simeq (3\times 10^8\gev)(100\gev/m)^{1/4}$. We discuss possible models in which such a field could arise.
Rangarajan, R., Srednicki, M.
openaire +3 more sources
A delayed 400 GeV photon from GRB 221009A and implication on the intergalactic magnetic field
Nature CommunicationsLarge High Altitude Air Shower Observatory has detected 0.2 − 13 TeV emission of GRB 221009A within 2000 s since the trigger. Here we report the detection of a 400 GeV photon, without accompanying prominent low-energy emission, by Fermi Large Area ...
Zi-Qing Xia +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Cryptobaryonic Dark Matter [PDF]
Physical Review Letters, 2005 It is proposed that dark matter could consist of compressed collections of atoms (or metallic matter) encapsulated into, for example, 20 cm big pieces of a different phase. The idea is based on the assumption that there exists at least one other phase of the vacuum degenerate with the usual one.
Froggatt, C. D., Nielsen, H. B.
openaire +3 more sources