Results 61 to 70 of about 214,465 (268)

Constraining primordial black holes as dark matter using AMS-02 data

European Physical Journal C: Particles and Fields
Primordial black holes (PBHs) are the plausible candidates for the cosmological dark matter. Theoretically, PBHs with masses $$M_{\textrm{PBH}}$$ M PBH in the range of $$4\times 10^{14}\sim 10^{17}\,\textrm{g}$$ 4 × 10 14 ∼ 10 17 g can emit sub-GeV ...
Bing-Yu Su, Xu Pan, Guan-Sen Wang, Lei Zu, Yupeng Yang, Lei Feng   +5 more
doaj   +1 more source

Evidence for dynamical dark energy with an evolving Hubble constant

Astronomy & Astrophysics
Context. Hubble constant tension, together with the recent indications of dynamical dark energy proposed from the Dark Energy Spectroscopic Instrument (DESI) baryon acoustic oscillation (BAO) measurements, poses significant challenges for the standard ...
Wang Yi-Ying, Li Yin-Jie, Fan Yi-Zhong
doaj   +1 more source

Dark matter–radiation interactions: the impact on dark matter haloes [PDF]

Monthly Notices of the Royal Astronomical Society, 2015
Interactions between dark matter (DM) and radiation (photons or neutrinos) in the early Universe suppress density fluctuations on small mass scales. Here we perform a thorough analysis of structure formation in the fully non-linear regime using N-body simulations for models with DM-radiation interactions and compare the results to a traditional ...
Schewtschenko JA, Wilkinson RJ, Baugh CM, Boehm C, Pascoli S   +4 more
openaire   +4 more sources

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Dark Matter “Collider” from Inelastic Boosted Dark Matter [PDF]

Physical Review Letters, 2017
We propose a novel dark matter (DM) detection strategy for the models with non-minimal dark sector. The main ingredients in the underlying DM scenario are a boosted DM particle and a heavier dark sector state. The relativistic DM impinged on target material scatters off inelastically to the heavier state which subsequently decays into DM along with ...
Kim D, Park JC, Shin S
openaire   +4 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

DARK ENERGY, DARK MATTER AND GRAVITY [PDF]

International Journal of Modern Physics D, 2007
We discuss the motivation for high accuracy relativistic gravitational experiments in the solar system and complementary cosmological tests. We focus our attention on the issue of distinguishing a generic scalar theory of gravity as the underlying physical theory from the usual general-relativistic picture, where one expects the presence of ...
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Dark matter as dark energy

Physics Letters B, 2003
Velocity-dependent interactions in a fundamental-string dominated universe lead quite naturally, with reasonable assumptions on initial conditions, to an accelerating expanding universe without assuming the existence of a cosmological constant. This result also holds generically for a universe dominated by moving extremal black holes, owing to a ...
openaire   +2 more sources