Results 111 to 120 of about 1,660,126 (341)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Exploring sub-GeV dark matter physics with cosmic ray and future telescopes
European Physical Journal C: Particles and FieldsIf sub-GeV dark matter (DM) annihilates into charged particles such as $$e^+ e^-$$ e + e - , $$\mu ^+ \mu ^-$$ μ + μ - , or $$\pi ^+ \pi ^-$$ π + π - , it generates an additional source of electrons and positrons in the cosmic ray (CR) population within ...
Guan-Sen Wang +3 more
doaj +1 more source
Signals of Supersymmetric Dark Matter [PDF]
, 1999 The Lightest Supersymmetric Particle predicted in most of the supersymmetric scenarios is an ideal candidate for the dark matter of cosmology. Their detection is of extreme significance today.
Abbas, Afsar
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Physical Review DWe propose a setup for the origin of dark matter based on spacetime with a warped extra dimension and three branes: the Planck brane, the TeV brane, at a (few) TeV scale ρT, and a dark brane, at a (sub-)GeV scale ρ1≲100 GeV≪ρT. The Standard Model (SM) is localized in the TeV brane, thus solving the Higgs hierarchy problem, while the dark matter χ, a ...
Fotis Koutroulis +3 more
openaire +2 more sources
Physics Letters B, 2013 7 pages, 5 figures, v3: version to appear in ...
Ho, Chiu Man, Scherrer, Robert J.
openaire +2 more sources
CTA sensitivity on TeV scale dark matter models with complementary limits from direct detection [PDF]
, 2022 Chaimongkol Duangchan +10 more
openalex +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source