Results 131 to 140 of about 43,670,075 (292)

Heavy Higgs boson production at colliders in the singlet-triplet scotogenic dark matter model

, 2017
We consider the possibility that the dark matter particle is a scalar WIMP messenger associated to neutrino mass generation, made stable by the same symmetry responsible for the radiative origin of neutrino mass.
José W.F. Valle, Rojas, N., Marco Aurelio Díaz, Urrutia, S., Sebastián Urrutia-Quiroga, Valle, J., Nicolás Rojas, Díaz, Marco A.   +7 more
core   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Novel collider signatures in the type-I 2HDM+a model

Journal of High Energy Physics
The 2HDM+a model is one of the main models used in the interpretations of dark matter searches at the LHC. So far, all the 2HDM+a benchmarks considered by the ATLAS and CMS experiments are limited to a type-II Yukawa sector, in which the Higgs bosons A ...
Spyros Argyropoulos, Ulrich Haisch, Ilia Kalaitzidou   +2 more
doaj   +1 more source

Detection of early-universe gravitational-wave signatures and fundamental physics. [PDF]

Gen Relativ Gravit, 2022
Caldwell R, Cui Y, Guo HK, Mandic V, Mariotti A, No JM, Ramsey-Musolf MJ, Sakellariadou M, Sinha K, Wang LT, White G, Zhao Y, An H, Bian L, Caprini C, Clesse S, Cline JM, Cusin G, Fornal B, Jinno R, Laurent B, Levi N, Lyu KF, Martinez M, Miller AL, Redigolo D, Scarlata C, Sevrin A, Haghi BSE, Shu J, Siemens X, Steer DA, Sundrum R, Tamarit C, Weir DJ, Xie KP, Yang FW, Zhou S.   +37 more
europepmc   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Dark fluxes from electromagnetic cascades

Journal of High Energy Physics
We study dark sector production in electromagnetic (EM) cascades. This problem requires accurate simulations of Standard Model (SM) and dark sector processes, both of which impact angular and energy distributions of emitted particles that ultimately ...
Nikita Blinov, Patrick J. Fox, Kevin J. Kelly, Pedro A. N. Machado, Ryan Plestid   +4 more
doaj   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Wearable E‐Textiles for Cardiovascular Monitoring: Materials, Devices, and Integrated Systems

Advanced Science, EarlyView.
The graphical abstract highlights the role of conductive materials and textile fabrication techniques in enabling smart textiles for cardiovascular applications. It showcases textile‐based ECG monitoring, pulse sensing, hemodynamic monitoring, and cardiovascular tissue engineering, while emphasizing the challenges and design considerations that govern ...
Bangul Khan, Mahmoud Tavakoli, Norbert Radacsi, Bee Luan KHOO   +3 more
wiley   +1 more source

Unveiling desert region in inert doublet model assisted by Peccei-Quinn symmetry

Journal of High Energy Physics
The Inert Higgs Doublet model (IDM), assisted by Peccei-Quinn (PQ) symmetry, offers a simple but natural framework of a dark sector that accommodates Weakly Interacting Massive Particle (WIMP) and axion as dark matter components.
Anupam Ghosh, Partha Konar
doaj   +1 more source