Results 151 to 160 of about 43,670,075 (292)

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

Advanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao, Jing Gao, Xiaohui Su, Xiangying Kong, Xiaolu Wei, Tunan Ding, Tiantian Guo, Shuangrong Gao, Yanyan Zhou, Junyi Zhou, Haiyu Zhao   +10 more
wiley   +1 more source

Collider signatures of near-continuum dark matter

Journal of High Energy Physics
A bstract In this paper we study a near-continuum dark matter model, in which dark sector consists of a tower of closely spaced states with weak-scale masses. We construct a five-dimensional model which naturally realizes this spectrum. The dark matter is
Ferrante, Steven, Lee, Seung, Perelstein, Maxim   +2 more
openaire   +4 more sources

gDM bounds - A portal to handle experimental limits on particle dark matter searche [PDF]

openThe nature of Dark Matter is still an open problem. One of the well known solution at TeV scale is WIMP scenario. There are three main methods employed in WIMPs' searches: using colliders, direct detection with nuclei and indirectly from ...
DE CARIA, MICHELA
core  

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Non‐Canonical Function of DDX21 in Fetal Hematopoiesis Antagonizes KDM5A‐Mediated Repression of Ribosomal and Hematopoietic Genes

Advanced Science, EarlyView.
This study demonstrates a mechanism by which RNA helicase DDX21 coordinates the transcription of hematopoietic and ribosomal genes by interacting with the H3K4me3 demethylase KDM5A. The DDX21‐KDM5A complex co‐occupies active genes in hematopoietic progenitors, thereby ensuring their rapid proliferation during fetal hematopoiesis.
Adrian On‐Wah Leung, Chang Li, Xianyin Huang, Zhuming Fan, Yuning Chen, Jiaxing Liu, Hong Man Lin, Xiaoming Cui, Fujia Zhang, Ruoxi Niu, Kam Tong Leung, Boxian Huang, Hoi‐Hung Cheung   +12 more
wiley   +1 more source

Dark matter with exotic mediators: the diquark portal

Journal of High Energy Physics
In this work we build out complete mediator sectors for models of frustrated dark matter (fDM), a new paradigm in which fermionic dark matter couples to the Standard Model (SM) through a scalar-fermionic mediator pair.
Linda M. Carpenter, Taylor Murphy
doaj   +1 more source

Dark Matter Jets at the LHC [PDF]

, 2012
We argue that dark matter particles which have strong interactions with the Standard Model particles are not excluded by current astrophysical constraints.
Bai, Yang, Rajaraman, Arvind
core  

A Single‐Capillary Open Microfluidic Probe for Robust and Versatile Spatial Multi‐Omics Using Ambient Mass Spectrometry Imaging

Advanced Science, EarlyView.
This study reports a knot‐shaped single‐capillary open microfluidic probe (Knot‐probe) for robust and versatile spatial omics, enabling ambient mass spectrometry imaging with high spatial resolution, throughput, and structure‐resolved capability. Knot‐probe mitigates the trade‐off between analytical performance and operational robustness, providing an ...
Xiangyu Zhu, Yunkai Li, Jianing Wang, Chengyi Xie, Lei Guo, Yanyan Chen, Thomas Ka‐Yam Lam, Shao‐Wen Shi, Kun Wang, Baoliang Chen, Zongwei Cai   +10 more
wiley   +1 more source

Probing Inert Triplet Model at a multi-TeV muon collider via vector boson fusion with forward muon tagging

Journal of High Energy Physics
This study investigates the potential of a multi-TeV Muon Collider (MuC) for probing the Inert Triplet Model (ITM), which introduces a triplet scalar field with hypercharge Y = 0 to the Standard Model.
Priyotosh Bandyopadhyay, Snehashis Parashar, Chandrima Sen, Jeonghyeon Song   +3 more
doaj   +1 more source

The search for charmed states of matter. [PDF]

Natl Sci Rev, 2021
Ball P.
europepmc   +1 more source