Results 111 to 120 of about 152,438 (313)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

THE EFFECT OF GROWTH REGULATORS AND CULTURE CONDITIONS ON THE CALLUS INDUCTION IN TOMATO Lycopersicon Sp.

open access: yesActa Scientiarum Polonorum: Hortorum Cultus, 2006
Effect of auxins: (NAA, IAA), cytokinin BAP and culture conditions (light, darkness) on callus induction in cotyledons of tomato cultivar ‘Maskotka’ and the wild form of Lycopersicon peruvianum was investigated.
Danuta Rzepka-Plevneš   +4 more
doaj  

DARK ENERGY WITHOUT DARK ENERGY [PDF]

open access: yesDark Matter in Astroparticle and Particle Physics, 2008
32 pages, 8 figures; Invited contribution to appear in the Proceedings of the Dark2007 Conference, Sydney, Australia, Sept 2007, eds H. Klapdor-Kleingrothaus and G.F. Lewis, (World Scientific, Singapore, 2008)
openaire   +2 more sources

In the Darkness, Everything Went All Black

open access: yes, 2018
Konceptdesign och scenografi till operan In the Darkness, Everything Went All ...
Jalhed, Hedvig,   +5 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Les ombres du polar

open access: yesMiranda: Revue Pluridisciplinaire du Monde Anglophone, 2013
By focusing on two notions, shadows and darkness, which are both prominent in US hardboiled/noir fiction from the1920s to the 1960s, this article offers two readings of the genre, as (1) the reenactment of an epic/shamanic narrative of incursion into the
Benoît Tadié
doaj   +1 more source

A Necessary Darkness

open access: yes, 2017
A Necessary Darkness 2017 - (commissioned by the Amsterdam Light Festival* in partnership with NEMO - the Dutch Museum of Science). a large scale projection on to the Renzo Piano designed ‘NEMO’ building (Oosterdok 2 Amsterdam) dusk - 11pm daily 30 ...
Lee, Rona
core  

Darkness. The Dynamics of Darkness in the North [PDF]

open access: yes, 2021
Defining darkness can be an impossible exercise to explain absence, nothingness, and the absolute all at once. Darkness falls within a system of symbolic values where colours are ascribed to meanings that are related to one another.The relationship ...
Jóhannesson, Gunnar Thór   +2 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

The first emerging records of a dragonfly in the dark zone of subterranean ecosystems: Exuviae and newly emerged adults of Hyrcanian Goldenring, Cordulegaster vanbrinkae in Danial Cave, northern Iran

open access: yesEcology and Evolution
Riverine caves are special habitats that are home to many aquatic and terrestrial species. Some Odonata species and their emerging are recorded at the entrance and in the twilight zones of subterranean habitats around the world. However, the emergence of
Pouria Ghelich Khani   +2 more
doaj   +1 more source

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