Results 111 to 120 of about 152,893 (314)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
[El superheterodino moderno] [PDF]
, 1954 Na capa posterior consta "Tecnica al día"Tít. consta na capaR. J.
Tur Tarrasa, Juan, Darkness, R. J. de
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Darkness. The Dynamics of Darkness in the North [PDF]
, 2021 Defining darkness can be an impossible exercise to explain absence, nothingness, and the absolute all at once. Darkness falls within a system of symbolic values where colours are ascribed to meanings that are related to one another.The relationship ...
Jóhannesson, Gunnar Thór +2 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Darkness, as a first act of creation [PDF]
Performances by Ramon Amaro, AmazonPrimeQueen (Victoria McKenzie), DeForrest Brown, Jr., Kepla (Jon Davies), Jorge Lucero Diaz, Conrad Moriarty-Cole. Audio contributions by Antonio Lara. Video directed and edited by Carlos Lopes.
Amaro, Ramon
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[Probadores de valvulas] [PDF]
, 1955 Na capa posterior: "Tecnica al dia"Tít. consta na capaR. J.
Tur Tarrasa, Juan, Darkness, R. J. de
core
, 2016 Darkness Underneath is an exegesis accompanying my creative thesis, Darkness Within, a young adult novel about a group of people going through major life changes following the death of Violet, a young woman who committed suicide.
Pitigaisorn, Panisa
core +2 more sources
Effects of Simulated Tunnel Darkness on Histology of Schizothorax macropogon
FishesSchizothorax macropogon is an endemic fish species of the Tibetan Plateau whose distribution largely overlaps with hydropower facilities. In this study, the fish were exposed to simulated tunnel darkness for 7 days to evaluate microstructural changes in ...
Yanlin Wei +6 more
doaj +1 more source