Results 131 to 140 of about 152,893 (314)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Configurations of imperialism and their displacements in the novels of Joseph Conrad. [PDF]

, 1998
PhDThis thesis examines certain configurations of imperialism and their displacements in the novels of Joseph Conrad beginning from the premise that imperialism is rationalised through a dualistic model of self/"other" and functions as a hierarchy of
Marcus, Miriam, Marcus, M.
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Theory of Dark Energy and Dark Matter

Journal of Mathematical Study, 2015
Summary: In a previous paper, a new set of gravitational field equations were derived based only on 1) the Einstein principle of general relativity, and 2) the principle of interaction dynamics, due to the the presence of dark energy and dark matter. With the field equations, we show that gravity can display both attractive and repulsive behavior, and ...
Hernandez, Marco, Ma, Tian, Wang, Shouhong   +2 more
openaire   +2 more sources

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Japońskie przekłady Heart of Darkness Josepha Conrada – słowa wspólne i przykłady rozbieżności [PDF]

The article offers an analysis of the complex process of reception and translation of Heart of Darkness in Japan. It explores the history of translations, the varied approaches and interpretations of Japanese translators and publishers, and the ongoing ...
Aleksandra Szczechla
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Darkness as an Anthropological Space. Perspectives Induced by Psalms 88 and 139 on the themes of Death, Life and the Presence of YHWH

Old Testament Essays, 2019
In this article an intertextual comparison is made between Pss 88 and 139 on the theme and use of the concept of “darkness.” In the meta-narrative of the shape and shaping of the Psalter, these two psalms are counterpointed to each other.
Lodewyk Sutton
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Shedding Light on the Darkness A Guide to Teaching the Holocaust [PDF]

Intro -- Shedding Light on the Darkness -- Copyright -- Contents -- Acknowledgments -- Introduction -- Part I -- Chapter 1. The Holocaust through Literature and Film -- Chapter 2. The Well-Utilized Survivor -- Chapter 3.
Lauckner, Nancy A., Jokiniemi, Miriam.
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