Results 151 to 160 of about 152,893 (314)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Injustice in Contemporary Islamic Theology: Explanation, Punishment and the Hereafter

Religions
Since the 1980s, a theology of injustice has gained prominence in Islamic thought as a large body of literature has been written on the subject. One of the main tenets of this theology is the punishment of injustice in the afterlife, which emphasizes how
Abdessamad Belhaj
doaj   +1 more source

In the dark [PDF]

Nature, 2013
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The darkness [PDF]

, 2018
Kasha has answered the advert for The Tribe. Now she sits writing alone in the darkness of the jungle. Is she the only one left? Then she spots a red light blinking at her from the darkness. Cat’s eyes?
Christopher, L
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

A Light in the Darkness [PDF]

, 2020
Even the darkest places are not out of reach from God’s light. The light shines in the darkness, and the darkness has not overcome it. - John 1:
Khabbaz, Joseph
core   +1 more source

Dancing in the Dark

Respiration, 2022
Ales Rozman, Lina Zuccatosta, Stefano Gasparini   +2 more
openaire   +3 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Urban Landscape Work Exhibited in 'The Witching Hour: Darkness and the Architectural Uncanny', PM Gallery & House, London, (21 Jan – 12 Mar 2011), curated by Matt Price. [PDF]

, 2011
Photographic work from Billingham's series 'Black Country' was exhibited in 'The Witching Hour: Darkness and the Architectural Uncanny', PM Gallery & House, London, (21 Jan – 12 Mar 2011), curated by Matt Price.
Billingham, Richard, PM Gallery & House
core