Results 131 to 140 of about 268,213 (316)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Darkness as an Anthropological Space. Perspectives Induced by Psalms 88 and 139 on the themes of Death, Life and the Presence of YHWH

Old Testament Essays, 2019
In this article an intertextual comparison is made between Pss 88 and 139 on the theme and use of the concept of “darkness.” In the meta-narrative of the shape and shaping of the Psalter, these two psalms are counterpointed to each other.
Lodewyk Sutton
doaj   +1 more source

The call of the dark continent : a study in missionary progress, opportunity and urgency [PDF]

, 1911
F. Deaville Walker
openalex   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

The dark bubbleography

Journal of High Energy Physics
Abstract We present the holographic construction of the dark bubble model of dark energy and highlight the pivotal role played by the non-normalizable modes. Following the route of holographic renormalization, we show that the non-normalizable modes are essential for having a vanishing mass for the induced graviton in any ...
Banerjee, Souvik, Danielsson, Ulf, Zemsch, Maximilian   +2 more
openaire   +4 more sources

Photoreversibility of Leaf and Hypocotyl Elongation of Dark Grown Red Kidney Bean Seedlings [PDF]

, 1955
R. J. Downs
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Sleeping in Beowulf

American and British Studies Annual, 2010
“Now I lay me down to sleep, I pray the Lord my soul to keep; if I should die before I wake, I pray the Lord my soul to take.” As this well-known little prayer suggests, during actual sleep—while the conscious faculties are inoperative—the soul is at ...
Kathleen Dubs
doaj  

Possible Interaction between Light-dark Cycles and Endogenous Daily Rhythms on the Growth of Tomato Plants. [PDF]

, 1954
H. R. Highkin, J. B. Hanson
openalex   +1 more source