Results 151 to 160 of about 332,113 (340)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

open access: yesFEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli   +15 more
wiley   +1 more source

Darkness as an Anthropological Space. Perspectives Induced by Psalms 88 and 139 on the themes of Death, Life and the Presence of YHWH

open access: yesOld Testament Essays, 2019
In this article an intertextual comparison is made between Pss 88 and 139 on the theme and use of the concept of “darkness.” In the meta-narrative of the shape and shaping of the Psalter, these two psalms are counterpointed to each other.
Lodewyk Sutton
doaj   +1 more source

The dark bubbleography

open access: yesJournal of High Energy Physics
Abstract We present the holographic construction of the dark bubble model of dark energy and highlight the pivotal role played by the non-normalizable modes. Following the route of holographic renormalization, we show that the non-normalizable modes are essential for having a vanishing mass for the induced graviton in any ...
Banerjee, Souvik   +2 more
openaire   +4 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

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