Results 71 to 80 of about 783,043 (296)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Ecology and EvolutionRiverine caves are special habitats that are home to many aquatic and terrestrial species. Some Odonata species and their emerging are recorded at the entrance and in the twilight zones of subterranean habitats around the world. However, the emergence of
Pouria Ghelich Khani +2 more
doaj +1 more source
How Eye Movements Stabilize Posture in Patients With Bilateral Vestibular Hypofunction
Frontiers in Neurology, 2018 Chronic patients with bilateral vestibular hypofunction (BVH) complain of oscillopsia and great instability particularly when vision is excluded and on irregular surfaces.
Michel Lacour +6 more
doaj +1 more source
Physics Letters B, 2003 Velocity-dependent interactions in a fundamental-string dominated universe lead quite naturally, with reasonable assumptions on initial conditions, to an accelerating expanding universe without assuming the existence of a cosmological constant. This result also holds generically for a universe dominated by moving extremal black holes, owing to a ...
openaire +2 more sources
Journal of Cosmology and Astroparticle Physics, 2012 We construct explicit models of particle dark matter where the attractive force in the dark matter sector creates a narrow near-threshold resonance that qualitatively changes the energy dependence of the annihilation cross section. In these models, the resonant enhancement of the dark matter annihilation can easily source the excess of energetic ...
An, Haipeng, Pospelov, Maxim
openaire +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Revista Brasileira de Fruticultura, 2009 O objetivo deste trabalho foi avaliar o efeito de diferentes concentrações do ácido indolbutírico (0 - controle; 500; 1.000; 1.500 e 2.000 mg L-1) no enraizamento de microestacas de mirtileiro de espécie e grupos distintos (cultivar O'Neal, Vaccinium sp.,
Cláudia Roberta Damiani +3 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Chronotype and response to training during the polar night: a pilot study
International Journal of Circumpolar Health, 2017 Background: An individual’s chronotype influences his or her physiological rhythms. Some studies have looked at the effect of time of day on the responses to exercise, but studies on the effect of long-term training are lacking. Objective: To report the
Jacopo Antonino Vitale +4 more
doaj +1 more source