Results 71 to 80 of about 152,438 (313)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Dark matter [PDF]

Proceedings of the National Academy of Sciences, 2014
The evidence for the dark matter (DM) of the hot big bang cosmology is about as good as it gets in natural science. The exploration of its nature is now led by direct and indirect detection experiments, to be complemented by advances in the full range of cosmological tests, including judicious consideration of the rich phenomenology of galaxies.
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Topological-darkness-assisted phase regulation for atomically thin meta-optics

, 2019
Two-dimensional (2D) noble-metal dichalcogenides have emerged as a new platform for the realization of versatile flat optics with a considerable degree of miniaturization.
Fei Qin (1315671), Dejiao Hu (5720084), Qingdong Ou (1731901), Yinan Zhang (136571), Bai-ou Guan (17513418), Jian Yuan (585683), Jun He (46556), Qiaoliang Bao (1423375), Yupeng Zhang (632467), Zi-Lan Deng (3981710), Yingwei Wang (256086), Xiangping Li (335253), Yaoyu Cao (3961616), Bo Peng (273834), Xu Ouyang (9326058), Chengwei Qiu (6184322)   +15 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Looking through the eyes of Job: A transpersonal–psychological perspective

HTS Teologiese Studies/Theological Studies, 2019
The current context of a turn to the visual and the transpersonal–psychological potential of the book of Job forms the background of this study, which aimed at focusing a psychological lens on the topic of eyes in the book of Job.
Pieter van der Zwan
doaj   +1 more source

Dark branes for dark matter

Physical Review D
We propose a setup for the origin of dark matter based on spacetime with a warped extra dimension and three branes: the Planck brane, the TeV brane, at a (few) TeV scale ρT, and a dark brane, at a (sub-)GeV scale ρ1≲100  GeV≪ρT. The Standard Model (SM) is localized in the TeV brane, thus solving the Higgs hierarchy problem, while the dark matter χ, a ...
Fotis Koutroulis, Eugenio Megías, Stefan Pokorski, Mariano Quirós   +3 more
openaire   +2 more sources

Darkness-dependent regulation of lrtA mRNA and protein levels.

, 2016
A, Total RNA was isolated from early-log-phase Synechocystis cells growing under normal illumination conditions (Light), after being subjected to darkness for 15, 30 or 60 min, and after re-illumination of the culture for 15 or 30 min. 15 μg of total RNA
M. Isabel Muro-Pastor (2147284), Francisco J. Florencio (227030), Carla V. Galmozzi (2147287)   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source