Results 81 to 90 of about 783,043 (296)
Revista Brasileira de Fruticultura, 2003 O trabalho foi realizado com o objetivo de testar a influência do AIB em condições de escuro, no enraizamento in vitro de amoreira-preta cv. Ébano.
Elizete Beatriz Radmann +2 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Controlling darkness: self, dark and the domestic night
, 2015 Social science research into darkness (and light) has largely focused on public spaces. In particular it has been interested in night-time cityscapes, but also spaces of leisure and rural landscapes.
Robert Shaw
semanticscholar +1 more source
Physical Review DWe propose a setup for the origin of dark matter based on spacetime with a warped extra dimension and three branes: the Planck brane, the TeV brane, at a (few) TeV scale ρT, and a dark brane, at a (sub-)GeV scale ρ1≲100 GeV≪ρT. The Standard Model (SM) is localized in the TeV brane, thus solving the Higgs hierarchy problem, while the dark matter χ, a ...
Fotis Koutroulis +3 more
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Melatonin, the Hormone of Darkness: From Sleep Promotion to Ebola Treatment.
Brain Disorders & Therapy, 2014 Melatonin is a hormone secreted by the enigmatic pineal gland in response to darkness, hence the name hormone of darkness. It has generated a great deal of interest as a therapeutic modality for various diseases particularly sleep disorders.
A. Masters +4 more
semanticscholar +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Methods for Assessment and Monitoring of Light Pollution around Ecologically Sensitive Sites
Journal of Imaging, 2019 Since the introduction of electric lighting over a century ago, and particularly in the decades following the Second World War, indications of artificial light on the nighttime Earth as seen from Earth orbit have increased at a rate exceeding that of ...
John C. Barentine
doaj +1 more source