Results 81 to 90 of about 268,213 (316)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

How Dark is ‘Dark’? Electromagnetic Interactions in the Dark Sector [PDF]

open access: yes, 2006
We review the physical and cosmological consequences of two possible electromagnetic couplings to the dark sector: (i) a neutral lightest dark-matter particle (LDP) with nonzero electric and/or magnetic dipole moments and (ii) a charged next-to-lightest dark-matter particle (NLDP) which decays to a neutral LDP.
openaire   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Chronotype and response to training during the polar night: a pilot study

open access: yesInternational Journal of Circumpolar Health, 2017
Background: An individual’s chronotype influences his or her physiological rhythms. Some studies have looked at the effect of time of day on the responses to exercise, but studies on the effect of long-term training are lacking. Objective:  To report the
Jacopo Antonino Vitale   +4 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Lignification in Scots Pine Callus as Reaction to Cultivation Conditions and Nutrient Medium [PDF]

open access: yesСибирский лесной журнал, 2014
The effect of nutrient medium composition and of the conditions of cultivation of Scots pine (Pinus sylvestris L.) callus on the morphology of its cells, the degree of their differentiation and lignification was studied. The morphological characteristics
G. F. Antonova   +2 more
doaj  

Can UV light induce movement in cage-free laying hens?

open access: yesJournal of Applied Poultry Research, 2023
SUMMARY: In recent years, more farms have been transitioning to cage-free systems as multiple states passed regulations banning use of conventional cages, and several large food service companies pledged to exclusively source cage-free eggs by 2025–2026.
A.V. Mendoza, S. Weimer, Z. Williams
doaj  

History, trauma, demystification and narration in the novels Darkness and Animal kingdom by David Albahari [PDF]

open access: yesBaština
The paper explores the issues of history, trauma, demystification, and narration present in the novels Darkness and Animal Kingdom, written by the Serbian writer David Albahari. It begins with an introduction that discusses Albahari's literary opus, with
Kovačević Darko M.
doaj   +1 more source

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