Results 81 to 90 of about 332,113 (340)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Karanlık Risalesi: Felsefeden Mistisizme

Eskiyeni
Genelde olumsuzlama cihetinden aydınlığın/nurun zıttı olarak kabul edilen karanlık, bu niteliği ile aydınlığın olmadığı bir durumu betimliyor olsa da onun nurun en parlak hâlini ifade ettiğini söylemek de mümkündür.
Mehmet Murat Karakaya
doaj   +1 more source

Franco Vaccari. Experiencing darkness towards Shamanism

Agathón, 2018
This paper examines one of the most symbolic and meaningful artworks by Franco Vaccari, Dark Sculpture, an artwork/temporary performance in which darkness becomes a play of presence-absence, inspired, both conceptually and visually, by the transition ...
Sergio Poggianella
doaj   +1 more source

A Dark Matter Model with Non-Abelian Gauge Symmetry [PDF]

Phys.Rev.D82:075003,2010, 2009
We propose a dark matter model in which the dark sector is gauged under a new SU(2) group. The dark sector consists of SU(2) dark gauge fields, two triplet dark Higgs fields, and two dark fermion doublets (dark matter candidates in this model). The dark sector interacts with the SM sector through kinetic and mass mixing operators.
arxiv   +1 more source

Dark energy: Staring into darkness [PDF]

Nature, 2016
The path to understanding dark energy begins with a single question: has it always been the same throughout the history of the Universe?
openaire   +2 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Composite Dark Matter with Forbidden Annihilation [PDF]

JHEP 09 (2024) 064
A dark matter model based on QCD-like $SU(N_c)$ gauge theory with electroweakly interacting dark quarks is discussed. Assuming the dark quark mass $m$ is smaller than the dynamical scale $\Lambda_d \sim 4\pi f_d$, the main component of the dark matter is the lightest $G$-parity odd dark pion associated with chiral symmetry breaking in the dark sector ...
arxiv   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Changes in the number and size of nucleoli of Chara vulgaris L. antheridial filament cells during the period preceding light-induced re-initiation of cell divisions following a mitodepressive effect of darkness

Acta Societatis Botanicorum Poloniae, 2014
The changes in number and size of nucleoli of Chara vulgaris antheridial filament cells were monitored with the use of Howell and Black's silver staining method.
Maria Kwiatkowska, Ewa Papiernik
doaj   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source