Results 11 to 20 of about 22,035 (254)

A novel simultaneous high performance liquid chromatography-PDA method for the determination of Tenofovir AF, Darunavir, Emtricitabine and Cobicistat in bulk and its application to marketed formulation

Future Journal of Pharmaceutical Sciences, 2022
Background The present research article involves the simultaneous determination of Tenofovir alafenamide, Darunavir, Emtricitabine and Cobicistat in bulk as well as in tablet dosage form using high performance liquid chromatography. Result The separation
Challamalla Pavani, E. Susithra
doaj   +2 more sources

Lopinavir/Ritonavir and Darunavir/Cobicistat in Hospitalized COVID-19 Patients: Findings From the Multicenter Italian CORIST Study

Frontiers in Medicine, 2021
Background: Protease inhibitors have been considered as possible therapeutic agents for COVID-19 patients.Objectives: To describe the association between lopinavir/ritonavir (LPV/r) or darunavir/cobicistat (DRV/c) use and in-hospital mortality in COVID ...
Augusto Di Castelnuovo, Simona Costanzo, Andrea Antinori, Nausicaa Berselli, Lorenzo Blandi, Marialaura Bonaccio, Raffaele Bruno, Raffaele Bruno, Roberto Cauda, Roberto Cauda, Alessandro Gialluisi, Giovanni Guaraldi, Lorenzo Menicanti, Marco Mennuni, Ilaria My, Agostino Parruti, Giuseppe Patti, Stefano Perlini, Stefano Perlini, Francesca Santilli, Carlo Signorelli, Giulio G. Stefanini, Alessandra Vergori, Walter Ageno, Luca Aiello, Piergiuseppe Agostoni, Piergiuseppe Agostoni, Samir Al Moghazi, Rosa Arboretti, Filippo Aucella, Greta Barbieri, Martina Barchitta, Alessandro Bartoloni, Carolina Bologna, Paolo Bonfanti, Paolo Bonfanti, Lucia Caiano, Laura Carrozzi, Antonio Cascio, Giacomo Castiglione, Mauro Chiarito, Arturo Ciccullo, Antonella Cingolani, Antonella Cingolani, Francesco Cipollone, Claudia Colomba, Crizia Colombo, Francesco Crosta, Giovanni Dalena, Chiara Dal Pra, Gian Battista Danzi, Damiano D'Ardes, Katleen de Gaetano Donati, Francesco Di Gennaro, Giuseppe Di Tano, Gianpiero D'Offizi, Tommaso Filippini, Francesco Maria Fusco, Carlo Gaudiosi, Ivan Gentile, Giancarlo Gini, Elvira Grandone, Gabriella Guarnieri, Gennaro L. F. Lamanna, Giovanni Larizza, Armando Leone, Veronica Lio, Angela Raffaella Losito, Gloria Maccagni, Stefano Maitan, Sandro Mancarella, Rosa Manuele, Massimo Mapelli, Massimo Mapelli, Riccardo Maragna, Riccardo Maragna, Lorenzo Marra, Giulio Maresca, Claudia Marotta, Franco Mastroianni, Maria Mazzitelli, Alessandro Mengozzi, Francesco Menichetti, Jovana Milic, Filippo Minutolo, Beatrice Molena, R. Mussinelli, Cristina Mussini, Maria Musso, Anna Odone, Marco Olivieri, Emanuela Pasi, Annalisa Perroni, Francesco Petri, Biagio Pinchera, Carlo A. Pivato, Venerino Poletti, Claudia Ravaglia, Marco Rossato, Marianna Rossi, Anna Sabena, Francesco Salinaro, Vincenzo Sangiovanni, Carlo Sanrocco, Laura Scorzolini, Raffaella Sgariglia, Paola Giustina Simeone, Michele Spinicci, Enrico Maria Trecarichi, Giovanni Veronesi, Roberto Vettor, Andrea Vianello, Marco Vinceti, Marco Vinceti, Elena Visconti, Laura Vocciante, Raffaele De Caterina, Licia Iacoviello, Licia Iacoviello, The COVID-19 RISK and Treatments (CORIST) Collaboration   +119 more
doaj   +2 more sources

Darunavir-cobicistat versus lopinavir-ritonavir in the treatment of COVID-19 infection (DOLCI): A multicenter observational study.

PLoS ONE, 2022
BackgroundCoronavirus Disease 2019 (COVID-19) is an evolving pandemic that urged the need to investigate various antiviral therapies. This study was conducted to compare efficacy and safety outcomes of darunavir-cobicistat versus lopinavir-ritonavir in ...
Eman Zeyad I Elmekaty, Rim Alibrahim, Rania Hassanin, Sitelbanat Eltaib, Ahmed Elsayed, Fatima Rustom, Mohamed Izham Mohamed Ibrahim, Mohammed Abu Khattab, Hussam Al Soub, Muna Al Maslamani, Abdullatif Al-Khal   +10 more
doaj   +2 more sources

Exploring the impact of baseline and on-treatment variables on durability of responses to fostemsavir through weeks 96 and 192 in the phase 3 BRIGHTE study. [PDF]

HIV Med
Abstract Objectives The gp120‐directed attachment inhibitor fostemsavir was effective in people with multidrug‐resistant (MDR) HIV‐1 in the BRIGHTE study. Understanding factors associated with virologic response can help clinicians optimize treatment and identify individuals for fostemsavir‐based regimens.
Gartland M, Wang X, Liao Q, Li B, Du F, Krystal M, Tenorio AR, Pierce A, Castillo-Mancilla JR.   +8 more
europepmc   +2 more sources

Intranasal Delivery of Darunavir-Loaded Mucoadhesive In Situ Gel: Experimental Design, In Vitro Evaluation, and Pharmacokinetic Studies

Gels, 2022
The clinical efficacy of antiretroviral therapy in NeuroAIDS is primarily limited by the low perfusion of the drug to the brain. The objective of the current investigation was to design and develop an in situ mucoadhesive gel loaded with darunavir to ...
Anroop B Nair, S. Chaudhary, Hiral Shah, S. Jacob, Vivek Mewada, P. Shinu, Bandar E. Aldhubiab, N. Sreeharsha, Katharigatta N. Venugopala, M. Attimarad, Jigar N. Shah   +10 more
semanticscholar   +1 more source

Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial.

The Lancet HIV, 2022
BACKGROUND WHO guidelines recommend dolutegravir plus two nucleoside reverse transcriptase inhibitors (NRTIs) for second-line HIV therapy, with NRTI switching from first-line tenofovir to zidovudine.
N. Paton, J. Musaazi, C. Kityo, S. Walimbwa, A. Hoppe, Apolo Balyegisawa, Jesca Asienzo, A. Kaimal, G. Mirembe, A. Lugemwa, Gilbert Ategeka, M. Borok, H. Mugerwa, A. Siika, E. L. Odongpiny, B. Castelnuovo, A. Kiragga, A. Kambugu, D. Kiiza, J. Kisembo, J. Nsubuga, Max Okwero, R. Muyise, Claire Nasaazi, D. Nakiboneka, J. Namusanje, Theresa Najjuuko, Timothy Masaba, T. Serumaga, Adolf Alinaitwe, Allan Arinda, A. Rweyora, Mary Goretti Kangah, M. Kasozi, Phionah Tukumushabe, Rogers Akunda, S. Makumbi, Sharif Musumba, Sula Myalo, John Ahuura, A. Namusisi, Daniel Kibirige, Francis Kiweewa, Habert Mabonga, Joseph Wandege, Josephine Nakakeeto, Sharon Namubiru, Winfred Nansalire, A. Siika, C. Kwobah, C. Mboya, M. Mokaya, M. Karoney, P. Cheruiyot, S. Cherutich, S. Njuguna, V. Kirui, E. Chidziva, G. Musoro, J. Hakim, J. Bhiri, M. Phiri, S. Mudzingwa, Tadios Manyanga, Anchilla Banegura, Betty Agwang, Brian Isaaya, Constantine Tumwine, E. L. Odongpiny, N. Paton, Peter Senkungu, Yvonne Kamara, Mathius Amperiize, Elizabeth Allen, C. Opondo, Perry Mohammed, Willemijn van Rein-van der Horst, Y. van Delft, F. A. Boateng, Doreen Namara, P. Kaleebu, S. Ojoo, T. Bwakura, Milly Katana, F. Venter, S. Phiri, S. Walker   +86 more
semanticscholar   +1 more source

Maintenance darunavir/ritonavir monotherapy to prevent perinatal HIV transmission, ANRS-MIE 168 MONOGEST study

Journal of Antimicrobial Chemotherapy, 2023
Objectives Because NRTIs can have fetal toxicities, we evaluated a perinatal NRTI-sparing strategy to prevent perinatal HIV transmission. Our primary objective was to determine the proportion maintaining a viral load (VL) of
L. Mandelbrot, R. Tubiana, P. Frange, G. Peytavin, J. Le chenadec, A. Canestri, P. Morlat, C. Brunet-cartier, J. Sibiude, D. Peretti, V. Chambrin, A. Chabrol, E. Bui, C. Simon-Toulza, L. Marchand, C. Paul, Sandrine Delmas, V. Avettand-Fenoel, J. Warszawski   +18 more
semanticscholar   +1 more source

Combinatorial approach of vitamin C derivative and anti-HIV drug-darunavir against SARS-CoV-2.

Frontiers in Bioscience, 2022
BACKGROUND Coronavirus disease-2019 (COVID-19) has become a pandemic around the globe due to the Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), a new variant of the Coronavirus (CoV) family.
Alaka Sahoo, S. S. Swain, B. Paital, M. Panda   +3 more
semanticscholar   +1 more source

Darunavir ethanolate: Repurposing an anti-HIV drug in COVID-19 treatment

European Journal of Medicinal Chemistry Reports, 2021
Antivirals already on the market and expertise gained from the SARS and MERS outbreaks are gaining momentum as the most effective way to combat the coronavirus outbreak.
Vivek P. Chavda, Normi D. Gajjar, N. Shah, D. Dave   +3 more
semanticscholar   +1 more source

Identification, Isolation, and Structural Characterization of Novel Forced Degradation Products of Darunavir Using Advanced Analytical Techniques Like UPLC–MS, Prep-HPLC, HRMS, NMR, and FT-IR Spectroscopy

Chromatographia, 2022
Since the stability of the pharmaceuticals plays a crucial role in efficacy and safety while using them in the treatment of disorders, the evaluation of purity and impurity profiling of pharmaceuticals is of utmost importance using efficient analytical ...
Arun Kumar Modini, M. Ranga, Umamaheshwar Puppala, Muralidharan Kaliyapermal, Mahesh Kumar Reddy Geereddy, R. Samineni, P. Grover, Dr. Sathish Kumar Konidala   +7 more
semanticscholar   +1 more source