Results 71 to 80 of about 46,296 (251)

The Impact of Non-Surgical Periodontal Therapy on P. gingivalis Count and DAS-28 Score in Periodontitis Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

F1000Research
Background Rheumatoid Arthritis, autoimmune disease primarily affecting the joints, has a bidirectional relationship with periodontitis since they share common characteristics. Non-surgical periodontal therapy (NSPT), which includes scaling and root planning (SRP) and oral hygiene instructions (OHI), is widely regarded as the ...
Ana Talia, Benso Sulijaya, Sandra Olivia Kuswandani, Herlis Rahdewati, Fatimah Maria Tadjoedin   +4 more
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Relationship Between Hand Grip and Pinch Strengths and Disease Activity, Articular Damage, Pain, and Disability in Patients with Rheumatoid Arthritis

The Turkish Journal of Gastroenterology, 2013
Objectives: This study aims to investigate the relationship of hand grip and pinch strengths with disease activity, functional impairment, functional disability, articular damage, pain, and disease duration in patients with rheumatoid arthritis (RA).
Meryem DEDEOĞLU, Ümit GAFUROĞLU, Özlem YILMAZ, Hatice BODUR   +3 more
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Markers of endothelial activation in rheumatoid arthritis

Терапевтический архив, 2012
Aim. To study relationships between endothelial activation parameters and inflammatory activity markers in patients with rheumatoid arthritis (RA). Subjects and methods. Fifty-three RA patients aged 19 to 62 years were examined. A control group comprised
N P Shilkina, I E Iunonin, A A Vinogradov, S V Butusova   +3 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

EFFECTS OF TIMING OF PREDNISOLONE ON THE DURATION OF EARLY MORNING STIFFNESS, PAIN AND DISEASE ACTIVITY SCORE (DAS-28) IN PATIENTS WITH RHEUMATOID ARTHRITIS

Pakistan Armed Forces Medical Journal, 2017
Objective: To determine the effects of timing of prednisolone on duration of early morning stiffness, pain score, number of swollen and tender joints, erythrocyte sedimentation rate (ESR) and disease activity score 28 (DAS-28) in joints in patients with
Haris Gul,, Amjad Nasim, Babur Salim
doaj   +2 more sources