Results 81 to 90 of about 9,813,695 (247)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
F1000ResearchBackground Rheumatoid Arthritis, autoimmune disease primarily affecting the joints, has a bidirectional relationship with periodontitis since they share common characteristics. Non-surgical periodontal therapy (NSPT), which includes scaling and root planning (SRP) and oral hygiene instructions (OHI), is widely regarded as the ...
Ana Talia +4 more
openaire +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Maximum Score Type Estimators [PDF]
This paper presents maximum score type estimators for linear, binomial, tobit and truncated regression models. These estimators estimate the normalized vector of slopes and do not provide the estimator of intercept, although it may appear in the model ...
Marcin Owczarczuk
core
The Turkish Journal of Gastroenterology, 2013 Objectives: This study aims to investigate the relationship of hand grip and pinch strengths with disease activity, functional impairment, functional disability, articular damage, pain, and disease duration in patients with rheumatoid arthritis (RA).
Meryem DEDEOĞLU +3 more
doaj
Association between mean platelet volume and severity of rheumatoid arthritis
The Pan African Medical Journal, 2017 INTRODUCTION: in recent years, it is suggested that platelet histogram indices, such as mean platelet volume (MPV) may be related to the activity of rheumatoid arthritis (RA).
Jamileh Moghimi +3 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Markers of endothelial activation in rheumatoid arthritis
Терапевтический архив, 2012 Aim. To study relationships between endothelial activation parameters and inflammatory activity markers in patients with rheumatoid arthritis (RA). Subjects and methods. Fifty-three RA patients aged 19 to 62 years were examined. A control group comprised
N P Shilkina +3 more
doaj