Results 91 to 100 of about 20,235 (287)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Molecular studies on a complex of potyviruses infecting solanaceous crops, and some specific virus-host interactions [PDF]

, 2003
This thesis constitutes a comprehensive analysis of the molecular and biological characteristics of three potyviruses (genus Potyvirus, family Potyviridae) naturally occurring in cultivated and wild species of family Solanaceae: Peru tomato virus (PTV ...
Spetz, Carl
core  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Detection of Prunus Necrotic Ringspot Virus (PNRSV) and Apple Mosaic Virus (ApMV) in Rose (Rosa spp.) Plants in Konya Province

Turkish Journal of Agriculture: Food Science and Technology
This research was conducted to determine the presence of Prunus necrotic ringspot virus (PNRSV) and Apple mosaic virus (ApMV) that can cause infection in rose (Rosa spp.) plants grown in Konya province. For this purpose, field and laboratory studies were
Adile Tuğçe Orhan, Serkan Yeşil
doaj   +1 more source

Development of a DAS-ELISA for Gyrovirus Homsa1 Prevalence Survey in Chickens and Wild Birds in China. [PDF]

Vet Sci, 2023
Zhang S, Yang J, Zhou D, Yan T, Li G, Hao X, Yang Q, Cheng X, Shi H, Liu Q, Li Y, Cheng Z.   +11 more
europepmc   +1 more source

Determinacion de la presencia de tomato rinsgspot virus -ToRSV, en cuatro huertos de arandanos y malezas asociadas en la VII Region. [PDF]

, 2006
41 p.Durante la temporada 2005 – 2006, se realizó un muestreo dirigido hacia plantas de arándanos (Vaccinium corymbosum) con síntomas atribuibles a enfermedades de naturaleza viral, con el fin de determinar e identificar la presencia y distribución del ...
Lolas Caneo, Mauricio (Prof. Informante), Reyes Garay, Edson Santiago, Sandoval Briones, Claudio (Prof. Guía)   +2 more
core  

Epidemiological analysis of clones and cultivars of potato in soil naturally infested with Ralstonia solanacearum Biovar 2. [PDF]

, 2011
Made available in DSpace on 2011-04-09T16:14:28Z (GMT). No. of bitstreams: 1 silveiraepidemiological.pdf: 448542 bytes, checksum: 6526745f9f40b99945292fc5dae236b0 (MD5) Previous issue date: 2007-11 ...
BARNI, V., DUARTE, V., FERNANDES, J. M., LOPES, C. A., MACIEL, J. L. N., MORAES, M. G., SILVEIRA, J. R. P.   +6 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source