Results 101 to 110 of about 8,534,074 (253)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Silymarin (Livergol®) Decreases Disease Activity Score in Patients with Rheumatoid Arthritis: A Non-randomized Single-arm Clinical Trial

open access: yesIranian Journal of Allergy, Asthma and Immunology, 2017
Rheumatoid arthritis (RA) is a chronic autoimmune disease, which can lead to joint destruction and disability. Pannus formation due to chronic synovitis is the hallmark of RA.
Mehrdad Shavandi   +6 more
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Analisis Respon Hidrologi terhadap Penerapan Teknik Konservasi Tanah di Sub DAS Lengkong menggunakan Model SWAT

open access: yes, 2014
Salah satu penyebab banjir dan erosi adalah kondisi biofisik di bagian hulu Daerah Aliran Sungai (DAS) yang sudah tidak dapat mendukung fungsi hidrologis DAS dengan baik, sehingga perlu dilakukan upaya-upaya penerapan teknik konservasi tanah yang tepat ...
Firdaus, Gunadi
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

A formação das pontes de hidrogênio

open access: yes, 2014
Discorre sobre a formação das ligações de hidrogênio, apresentando suas características e formaçãoEnsino Médio::QuímicaEnsino Médio ...
Chagas, Evelize Folly das
core  

A importância da contabilidade no processo decisório das micro e pequenas empresas [PDF]

open access: yes, 2007
TCC (Graduação) - Universidade Federal de Santa Catarina. Centro Socioeconômico. Curso de Ciências ContábeisEste trabalho desenvolve um estudo sobre a importância da Contabilidade no processo decisório das Micro e Pequenas Empresas, mostrando a ...
Virgílio, Maria das Graças
core  

“Green July” 2020 and Another Good Reason to Quit Smoking: Help to Stop Spreading SARS-COV-2 and Save Lives!

open access: yesInternational Archives of Otorhinolaryngology, 2020
Marilia D'Elboux Guimarães Brescia   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

A formação das pontes de hidrogênio

open access: yes, 2011
Discorre sobre a formação das ligações de hidrogênio, apresentando suas características e formaçãoEnsino Médio::QuímicaEnsino Médio ...
Chagas, Evelize Folly das
core  

Home - About - Disclaimer - Privacy