Results 81 to 90 of about 8,534,074 (253)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Egyptian Rheumatology and Rehabilitation, 2014 Aim of Work To detect the prevalence of 25-hydroxyvitamin D 3 [25(OH)D 3 ] deficiency in rheumatoid arthritis (RA) patients and its correlation with disease activity, functional disability and bone mineral density (BMD).
Nashwa T Allam +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Correlation Between Level of Interleukin-37 and Rheumatoid Arthritis Progression
International Journal of General Medicine, 2021 Jifeng Zhu, Chuanjiang Xie, Hongjiu Qiu, Ling Shi Orthopedic Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, People’s Republic of ChinaCorrespondence: Ling ShiOrthopedic Surgery, Daping Hospital, Army Medical University ...
Zhu J, Xie C, Qiu H, Shi L
doaj
Frequency of Positive Anti-CCP Antibodies in Patients of Rheumatoid Arthritis with Negative Rheumatoid Factor: A Cross-sectional Retrospective Data-based Study [PDF]
Indian Journal of Medical BiochemistryObjective: To investigate the frequency of positive anti-cyclic citrullinated peptide (CCP) antibodies in rheumatoid arthritis (RA) patients with negative rheumatoid factor (RF) from Lahore, Pakistan.
Nauman Ismat Butt +1 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The Association of Anti-CCP and Disease Activity in Rheumatoid Arthritis
Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2014 Purpose: To determine the value of Anti-CCP as predictor for disease activity in rheumatoid arthritis assessed by DAS-28, and to find the effect of smoking on disease activity in rheumatoid arthritis.
Raouf Rahim Merza +3 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A IMPORTÂNCIA DA INFORMAÇÃO FINANCEIRA NAS EMPRESAS PORTUGUESAS: O JUSTO VALOR DO ATIVO FIXO TANGÍVEL [PDF]
, 2016 RESUMO Motivação: A União Europeia preconizou, através do Regulamento 1606/2002, a obrigatoriedade da adoção das normas do IASB nas contas consolidadas de todas as empresas cotadas em bolsas europeias, a partir de 1 de Janeiro de 2005.
Paiva, Inna +5 more
core +1 more source