Results 91 to 100 of about 46,962 (257)

Aggressive Glioblastoma Cells Enhance the Migratory Persistence and Velocity of Less Aggressive Cells to Promote Tumor Dissemination

Small, EarlyView.
We identify biophysical motility parameters explaining how less aggressive EGFRwt‐overexpressing Glioblastoma cells become more infiltrative when influenced by aggressive EGFRvIII‐expressing cells. Using bulk assays and microfluidic chips, we show that EGFRvIII cells enhance velocity and persistence in EGFRwt cells via Src‐mediated communication ...
Fatima‐ezzahra Ait Mohand, Shaked Yemini, Irina Gorobetz‐Cojocari, Ariel M Rubinstein, Assaf Zemel, Nataly Kravchenko‐Balasha   +5 more
wiley   +1 more source

Dasatinib Inhibits Lung Cancer Cell Growth and Patient Derived Tumor Growth in Mice by Targeting LIMK1

Frontiers in Cell and Developmental Biology, 2020
Lung cancer is a leading cause cancer-related death with diversity. A promising approach to meet the need for improved cancer treatment is drug repurposing.
Man Zhang, Jie Tian, Rui Wang, Mengqiu Song, Mengqiu Song, Ran Zhao, Ran Zhao, Hanyong Chen, Kangdong Liu, Kangdong Liu, Jung-Hyun Shim, Jung-Hyun Shim, Feng Zhu, Zigang Dong, Zigang Dong, Mee-Hyun Lee, Mee-Hyun Lee, Mee-Hyun Lee   +17 more
doaj   +1 more source

Dasatinib Ointment Promotes Healing of Murine Excisional Skin Wound [PDF]

, 2023
Surasak Wichaiyo, Saovaros Svasti, Arnatchai Maiuthed, Pattarawit Rukthong, Arman Syah Goli, Noppawan Phumala Morales   +5 more
openalex   +1 more source

Dasatinib-Induced Pulmonary Arterial Hypertension Treated with Upfront Combination Therapy

Case Reports in Cardiology, 2018
Pulmonary arterial hypertension (PAH) is a rare complication of dasatinib that was approved as a first-line therapy for chronic myelocytic leukemia (CML). A 24-year-old man presenting dyspnea at rest and leg edema was admitted to our hospital.
Makoto Nishimori, Tomoyuki Honjo, Kenji Kaihotsu, Naohiko Sone, Sachiko Yoshikawa, Junichi Imanishi, Kazuhiko Nakayama, Noriaki Emoto, Masanori Iwahashi   +8 more
doaj   +1 more source

Dasatinib-induced nephrotic syndrome in a patient with chronic myelogenous leukemia: a case report

BMC Nephrology, 2019
Background Dasatinib is a second-generation tyrosine kinase inhibitor that is indicated for the treatment of patients with chronic myeloid leukemia. Here, we report the case of a man with nephrotic syndrome that was caused by dasatinib. Case presentation
Shoko Ochiai, Yuji Sato, Akihiro Minakawa, Akihiro Fukuda, Shouichi Fujimoto   +4 more
doaj   +1 more source

Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options [PDF]

, 2018
The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate ...
Koschmieder, Steffen, Vetrie, David
core   +1 more source

Toward the harmonization of bioequivalence guidelines in Europe: Commentary on the state of the art and future priorities under ICH M13A for immediate‐release oral forms

British Journal of Clinical Pharmacology, EarlyView.
Domenico Nocera, Giusi Forastiero, Andrea Logreco, Alessia Proietti, Antonio Galluccio, Carlotta Lunghi, Elisabetta Poluzzi, Fabrizio De Ponti   +7 more
wiley   +1 more source

Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies

Cancer Science, EarlyView.
Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji, Narikazu Boku, Jun Adachi   +2 more
wiley   +1 more source

Dasatinib-induced hemorrhagic colitis complicated with cytomegalovirus infection

Hematology Reports, 2017
A 69-year-old man with chronic-phase chronic myeloid leukemia was initially treated with 100 mg dasatinib once a day. Despite a major molecular response within 9 months, he developed hemorrhagic colitis 32 months after starting dasatinib.
Aya Nakaya, Yoshiko Azuma, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yukie Tsubokura, Akiko Konishi, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Tomoki Ito, Shosaku Nomura   +11 more
doaj   +1 more source

IAP Antagonists Selectively Eliminate Therapy‐Induced Senescent Cancer Cells via TNFα‐Independent Apoptosis

Cancer Science, EarlyView.
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, Koji Ando, Eiji Oki, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao   +7 more
wiley   +1 more source