Results 101 to 110 of about 29,286 (231)

Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with dasatinib at 100 mg or 50 mg daily

Haematologica, 2011
Dasatinib is considered an effective drug in imatinib-resistant chronic myeloid leukemia. Although reported to be well-tolerated, severe events such as pleural or pericardial effusion have been reported at 140 mg daily.
Maria-Theresa Krauth, Susanne Herndlhofer, Maria-Theresa Schmook, Gerlinde Mitterbauer-Hohendanner, Ernst Schlögl, Peter Valent   +5 more
doaj   +1 more source

Dasatinib-Induced Chylothorax in Chronic Myeloid Leukemia

, 2017
Pulmonary adverse events are common abnormalities associated with the use of dasatinib in chronic myeloid leukemia. We present a case of a 69-year-old man who suddenly developed a rare chylothorax pulmonary adverse event following 10 months of dasatinib ...
Baloch, Zulfiqar Zulfiqar Qutrio Baloch Qutrio, Shabber, Agha Abbas, Karar, Sayed, Hammad, Bhatti   +3 more
core   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Análisis de costo-efectividad de dasatinib, comparado con nilotinib como tratamiento de segunda línea en pacientes diagnosticados con Leucemia Mieloide Crónica [PDF]

, 2018
Objetivo: Evaluar la relación costo-efectividad de los tratamientos de segunda línea en pacientes diagnosticados de leucemia mieloide crónica (LMC), resistentes o intolerantes a imatinib, en fase crónica.
Quitián Reyes, David
core  

Figure S4. Increased selumetinib sensitivity when dasatinib-resistant cell lines are maintained in 2μM dasatinib. from The Mitogen-Activated Protein Kinase Pathway Facilitates Resistance to the Src Inhibitor Dasatinib in Thyroid Cancer

, 2016
BCPAP, SW1736, C643, Cal62 control (C), dasatinib-resistant (DR), and dasatinib-resistant cells maintained in 2μM dasatinib in response to indicated concentrations of selumetinib (μM) for 72 hours. Growth was measured by Sulforhodamine B.
Kelsey E. Wuensch (15074598), Brittelle E. Kessler (15074601), Rebecca E. Schweppe (14993610), Maia L. Corpuz (15074604), Katie M. Mishall (15074592), Xia Jing (3255219), Jihye Kim (344025), Guoliang Wang (440255), Qiong Zhou (169101), Thomas C. Beadnell (14915583), Stephen M. Riffert (15074595), Aik Choon Tan (7497764)   +11 more
core   +1 more source

Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Kinetic profiling of 172 compounds across KIT conformations—including D816V—reveals kinetic fingerprints that predict efficacy, selectivity, resistance, and inhibitors’ ability to stabilize key regulatory elements. Far from a secondary metric, binding kinetics provide mechanistic insights beyond affinity, offering a powerful framework for rational drug
Ana Corrionero, Niall Prendiville, Tatiana Cazorla, Maria Baena‐Nuevo, Röhm Sandra, Emilio Camafeita, Stefan Knapp, Patricia Alfonso   +7 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

Carbon paste electrode modified with Bi2WO6 nanosheets and ionic liquid: voltammetric assay of dasatinib in the presence of doxorubicin as two anticancer drugs in pharmaceutical and biological samples

Journal of Electrochemical Science and Engineering
The main goal of this effort is to create an innovative electrochemical sensor for dasatinib detection in the presence of doxorubicin. It was possible to create Bi2WO6 nanosheets easily.
Mayada Hadi Al-qassi, Wisam Hashim Baqer, Abdul Amir H. Kadhum   +2 more
doaj   +1 more source