Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy [PDF]
, 2017 Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease; the identification of novel targets and development of effective treatment strategies are urgently needed to improve patient outcomes.
Olson, Michael F. +4 more
core +1 more source
Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review
Medicine Bulletin, EarlyView.ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng +8 more
wiley +1 more source
Med Research, EarlyView.Intra‐tumour heterogeneity is present in gastrointestinal tumours at the single‐cell level. Cell cycling, EMT, MYC and TNF‐α are the four main consensus meta‐programs in gastrointestinal tumours. Then, a prognostic model based on intratumoral heterogeneity was constructed using an artificial intelligence‐derived prognostic index.
Zhizhan Ni +12 more
wiley +1 more source
Case Reports in Hematology, 2020 Dasatinib, a second-line tyrosine kinase inhibitor (TKI), has been widely used in chronic myeloid leukemia (CML) and Philadelphia-positive B-cell acute lymphoblastic leukemia (Ph + B-ALL).
Xin Liao +3 more
doaj +1 more source
Dasatinib reverses drug resistance by downregulating MDR1 and Survivin in Burkitt lymphoma cells [PDF]
, 2020 Mitsuki Tabata +8 more
openalex +1 more source
CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling
Med Research, EarlyView.CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li +8 more
wiley +1 more source
Клиническая онкогематология, 2017 Background & Aims. The article presents results of two observational, prospective, multicenter studies “Quality of Life, Symptom Profile, and Adherence to Treatment in Adult Patients with Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia Receiving ...
Tat’yana Ivanovna Ionova +12 more
doaj +1 more source
Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers. [PDF]
Aging CellThe SC subtype with a pro‐inflammatory, proapoptotic, tissue‐damaging SASP is susceptible to senolytics. The SC subset not killed by senolytics has a pro‐growth/repair SASP. “Senosensitizers” that induce senolytic‐resistant SCs to be converted into SCs that are susceptible to senolytics could enable removal of relatively silent SCs.
Tripathi U +21 more
europepmc +2 more sources
Senolytic Treatment With Dasatinib and Quercetin Reshapes Influenza-Specific CD8 T Cell Responses During Infection in Aged, Vaccinated Mice. [PDF]
Aging CellImpaired vaccination responses leave older adults more vulnerable to severe influenza (flu) infections. Pretreatment with senolytic Dasatinib and Quercertin (D + Q) did not improve vaccine responses but altered some responses to sublethal flu challenge. Despite these changes, overall flu outcomes were not impacted.
Cadar AN +10 more
europepmc +2 more sources
Combined BRAFV600E- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer [PDF]
, 2014 Anaplastic (ATC) and refractory papillary thyroid cancer (PTC) lack effective treatments. Inhibition of either oncogenic BRAF or SRC has marked anti-tumor effects in mouse models of thyroid cancer, however, neither drug induces notable apoptosis. Here we
Bernasconi, Maria +6 more
core +1 more source